Skip to main content

Table 2 Correlation of Dual-energy CT Quantitative Parameters with Immunohistochemical Biomarkers

From: Dual-energy CT quantitative parameters for evaluating Immunohistochemical biomarkers of invasive breast cancer

Parameters

ER

p value

PR

p value

HER2

p value

Ki67

p value

Positive

Negative

Positive

Negative

Positive

Negative

High-proliferation

Low-proliferation

Arterial phase NIC

0.109 ± 0.067

0.133 ± 0.055

0.069

0.101 ± 0.063

0.128 ± 0.064

0.022

0.114 ± 0.058

0.117 ± 0.069

0.850

0.130 ± 0.063

0.096 ± 0.064

0.005

Venous phase NIC

0.336 ± 0.143

0.411 ± 0.133

0.003

0.317 ± 0.138

0.388 ± 0.133

0.005

0.381 ± 0.120

0.342 ± 0.149

0.138

0.409 ± 0.129

0.283 ± 0.120

<0.001

Arterial phase nZeff

0.72 ± 0.04

0.73 ± 0.04

0.164

0.72 ± 0.03

0.73 ± 0.04

0.437

0.73 ± 0.03

0.72 ± 0.05

0.077

0.74 ± 0.03

0.71 ± 0.05

<0.001

Venous phase nZeff

0.86 ± 0.06

0.88 ± 0.03

0.011

0.86 ± 0.06

0.87 ± 0.04

0.425

0.88 ± 0.03

0.86 ± 0.06

0.022

0.88 ± 0.04

0.85 ± 0.06

<0.001

Arterial phase λHu (HU/keV)

1.71 ± 0.84

1.94 ± 0.88

0.181

1.64 ± 0.85

1.88 ± 0.84

0.127

1.86 ± 0.76

1.72 ± 0.90

0.358

1.87 ± 0.96

1.64 ± 0.67

0.129

Venous phase λHu (HU/keV)

2.63 ± 0.98

2.75 ± 1.01

0.567

2.64 ± 0.85

2.68 ± 0.98

0.848

2.79 ± 0.95

2.58 ± 1.01

0.252

2.72 ± 1.10

2.58 ± 0.81

0.421

  1. Note—NIC normalized iodine concentration; nZeff normalized effective atomic number; λHu slope of the spectral Hounsfield unit curve; HU hounsfield unit; ER estrogen receptor; PR progesterone receptor; HER2 human epidermal growth factor receptor 2