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Table 3 Univariate and multivariate Cox regression analyses for patients in the training cohort

From: A radiomics nomogram for the prediction of overall survival in patients with hepatocellular carcinoma after hepatectomy

Variables

Univariate analysis

Multivariate analysis

HR (95%CI)

p

HR (95%CI)

p

Age, years

0.986 (0.971–1.000)

0.052

  

Sex, male vs. female

1.675 (0.964–2.911)

0.067

  

BMI, Kg/m2

 <18.5vs.18.5–25

0.944 (0.455–1.957)

0.876

  

 25vs.18.5–25

1.171 (0.539–2.541)

0.691

  

HBsAg, Positive vs. Negative

1.950 (1.079–3.523)

0.027

  

HBV-DNA, copies/ml, <103 vs. ≥ 103

1.740 (1.223–2.476)

0.002

  

Liver cirrhosis, Present vs. Absent

0.826 (0.583–1.171)

0.283

  

Child-Pugh classification, B vs. A

1.684 (0.825–3.438)

0.152

  

Previous abdominal surgery, Present vs. Absent

0.893 (0.562–1.420)

0.632

  

Comorbidities, Present vs. Absent

1.016 (0.668–1.546)

0.941

  

AFP, ng/mL, ≥ 400vs.<400

1.931 (1.388–2.688)

< 0.001

1.566 (1.101–2.226)

0.013

CEA, ng/mL, Normal vs. Abnormal

0.656 (0.419–1.027)

0.065

  

CA19–9, U/ml, Normal vs. Abnormal

1.131 (0.807–1.585)

0.474

  

TBIL, umol/L

1.000 (0.988–1.013)

0.940

  

DBIL, umol/L

0.999 (0.982–1.016)

0.901

  

ALT, IU/L

1.000 (0.999–1.002)

0.823

  

AST, IU/L

1.000 (0.999–1.002)

0.423

  

Albumin, g/L, <35vs. ≥ 35

1.322 (0.732–2.390)

0.355

  

NLR

1.085 (1.030–1.143)

0.002

  

PLR

1.006 (1.004–1.009)

< 0.001

1.004 (1.001–1.007)

0.010

ASA grade, III vs. II

1.362 (0.910–2.039)

0.133

  

Largest tumor size, cm

1.193 (1.145–1.244)

< 0.001

1.084 (1.027–1.145)

0.003

Tumor number, Solitary vs. Multiple

1.314 (0.710–2.432)

0.384

  

Hepatectomy, Anatomical vs. Nonanatomical

0.755 (0.538–1.060)

0.105

  

Hemorrhage, ml, ≥ 200vs.<200

1.927 (1.310–2.836)

0.001

  

Intraoperative transfusion, Yes vs. No

1.860 (1.104–3.132)

0.020

  

Differentiation, poor vs. Well-moderate

1.598 (1.148–2.225)

0.006

  

MVI, Present vs. Absent

3.524 (2.524–4.921)

<0.001

2.509 (1.751–3.594)

<0.001

Capsule, Incomplete vs. Complete

1.891 (1.324–2.702)

< 0.001

  

Rad-score

1.493 (1.324–1.684)

< 0.001

1.398 (1.188–1.646)

<0.001

  1. ASA American Society of Anesthesiologists, BMI Body mass index, AFP α-fetoprotein, ALT Alanine transaminase, AST Aspartate aminotransferase, NLR Neutrophil-to-lymphocyte ratio, PLR Platelet lymphocyte ratio, MVI Microvascular invasion, Rad-score Radiomics score
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