| |
Univariate analysis
|
Multivariate analysis
|
|---|
|
p value
|
HR
|
95%CI
|
p value
|
HR
|
95%CI
|
|---|
|
Age (years)
|
0.520
|
1.008
|
0.983–1.034
| | | |
|
Sex (female)
|
0.878
|
1.036
|
0.660–1.627
| | | |
|
Etiology (HCV)
|
0.004
|
2.426
|
1.334–4.411
|
0.006
|
2.438
|
1.293–4.599
|
|
Child–Pugh class (A)
|
0.007
|
0.492
|
0.294–0.823
|
0.042
|
0.524
|
0.281–0.976
|
|
Platelets (×104/μL)
|
0.742
|
0.994
|
0.957–1.031
| | | |
|
ALT (IU/L)
|
0.048
|
1.006
|
1.000–1.012
|
0.873
|
1.001
|
0.993–1.008
|
|
Hyaluronic acid (ng/mL)
|
< 0.001
|
1.001
|
1.001–1.002
|
0.575
|
1.000
|
0.999–1.001
|
|
Type IV collagen 7S (ng/mL)
|
0.000
|
1.146
|
1.073–1.224
|
0.130
|
1.080
|
0.978–1.192
|
|
Tumor size (mm)
|
0.037
|
1.040
|
1.002–1.079
|
0.573
|
1.012
|
0.971–1.054
|
|
Number of tumors
|
< 0.001
|
2.172
|
1.459–3.235
|
0.005
|
1.930
|
1.219–3.057
|
|
AFP (ng/mL)
|
0.120
|
1.001
|
1.000–1.001
| | | |
|
AFP-L3 (> 15%)
|
0.084
|
1.725
|
0.929–3.205
| | | |
|
DCP (mAU/mL)
|
0.282
|
1.000
|
1.000–1.000
| | | |
|
PET positive
|
0.021
|
2.425
|
1.144–5.138
|
0.112
|
1.969
|
0.854–4.540
|
- HR hazard ratio, CI confidence interval, HCV hepatitis C virus, ALT alanine aminotransferase, HCC hepatocellular carcinoma, AFP alpha-fetoprotein, AFP-L3 Lens culinaris agglutinin-reactive alpha-fetoprotein, DCP, Des-gamma-carboxyprothrombin, PET positron emission tomography
