Fig. 8From: The utility of pharmacological and radiological interventions to optimize diagnostic information from PET/CTExample of metformin effect. At baseline (a) metformin obscured uptake in a known rectal cancer. The baseline uptake in the primary tumour is demonstrated on the fused PET/MRI (b) but adjacent uptake in normal bowel compromised assessment of disease extent. The post-treatment scan (c) done with metformin withdrawal for 48 h demonstrated a complete metabolic response, which would otherwise have been impossible to discernBack to article page