Table 2 Immunohistochemical biomarkers in primary hepatic malignant vascular tumor
Immunohistochemical biomarkers | PHA | EHE | MHP | IHE |
|---|---|---|---|---|
Epithelial marker | ||||
CK | 7 (64%) | 8 (53%) | 0 | 2 (15%) |
Hepatocytes | 6 (55%) | 4 (27%) | 0 | 0 |
CK8/18 | 6 (55%) | 6 (40%) | 0 | 0 |
Vascular endothelial marker | ||||
CD31 | 11 (100%) | 15 (100%) | 3 (100%) | 13 (100%) |
CD34 | 11 (100%) | 15 (100%) | 3 (100%) | 13 (100%) |
ERG | 9 (82%) | 13 (87%) | 2 (67%) | 13 (100%) |
FaVIII | 9 (82%) | 9 (60%) | 1 (33%) | 7 (54%) |
FLI-1 | 9 (82%) | 9 (60%) | 1 (33%) | 7 (54%) |
Mesenchymal marker | ||||
Vimentin | 4 (36%) | 2 (13%) | 0 | 0 |
EMA | 3 (27%) | 0 | 0 | 0 |
CD117 | 2 (18%) | 0 | 0 | 0 |
Dog-1 | 0 | 0 | 0 | 0 |
Perivascular epithelioid cell marker | ||||
HMB45 | 0 | 0 | 2 (67%) | 0 |
Melan-A | 0 | 0 | 2 (67%) | 0 |
Cell proliferation marker | ||||
Ki-67, median, % (range) | 30 (1–60) | 5 (2–20) | 30 (10–30) | 10 (1–20) |