Table 1 Comparison of baseline patient’s characteristics based on whole-body bone SPECT/CT results
Characteristic | Total (N = 115) | Negative bone SPECT/CT (N = 88) | Positive bone SPECT/CT (N = 27) | P value |
|---|---|---|---|---|
Age (years) | ||||
Median ± (IQRs) | 73.2 (56–89) | 73.2 (67.2–80) | 73.2 (66–81.3) | 0.79 |
Initial PSA (ng/mL) | ||||
Median ± (IQRs) | 9.4 (7.1–18.4) | 9.2 (7.2–17.3) | 9.4 (6.5–33.5) | 0.45 |
Initial PSA (ng/mL), class n (%) | 0.18 | |||
0–10 | 65 (56.5) | 49 (55.7) | 16 (59.2) | |
10.01–20 | 26 (22.6) | 23 (26) | 3 (11.1) | |
> 20 | 24 (20.9) | 16 (18) | 8 (29.6) | |
Tumor (T) stage, n (%) | 0.10 | |||
T1 – T2a | 34 (30.6) | 30 (35.7) | 4 (14.8) | |
T2b | 16 (14.4) | 12 (14.3) | 4 (14.8) | |
T2c – T4 | 61 (55) | 42 (50) | 19 (70.4) | |
Gleason score, n (%) | < 0.01 | |||
≤ 6 | 32 (27.8) | 31 (35.2) | 1 (3.7) | |
7 (3–4) | 29 (25.2) | 24 (27.3) | 5 (18.5) | |
7 (4 + 3) | 30 (26.1) | 21 (23.9) | 9 (33.3) | |
≥ 8 | 24 (20.9) | 12 (13.6) | 12 (44.4) | |
D’Amico classification, n (%) | 0.09 | |||
Low-risk | 10 (8.7) | 10 (11.4) | 0 (0) | |
Intermediate-risk | 29 (25.2) | 24 (27.3) | 5 (18.5) | |
High-risk | 76 (66.1) | 54 (61.3) | 22 (81.5) | |
Initial treatment, n (%) | 0.98 | |||
RP | 13 (11.3) | 10 (11.4) | 3 (11.1) | |
RP + EBRT | 34 (29.6) | 27 (30.7) | 7 (25.9) | |
With positive surgical margins | 22 (19) | 15 (17) | 7 (26) | 0.15 |
EBRT | 50 (43.5) | 34 (42) | 13 (48.2) | |
Other (Brachytherapy, HIFU) | 18 (15.6) | 14 (15.9) | 4 (14.8) | |
Adjuvant ADT | 60 (52.2) | 42 (47.7) | 18 (66.7) | 0.09 |
PSA nadir (ng/mL), median ± (IQRs) | 0.1 (0.0–0.7) | 0.1 (0.0–0.7) | 0.1 (0.0–0.4) | 0.62 |
Trigger PSA (ng/mL), median ± (IQRs) | 5 (2.4–9.9) | 4.4 (2.1–6.9) | 12.5 (4.4–18.6) | < 0.001 |
Trigger PSA (ng/mL), class n (%) | < 0.001 | |||
PSA ≤10 ng /mL, | 87 (75.7) | 74 (84.1) | 13 (48.2) | |
PSA > 10 ng/mL | 28 (24.4) | 14 (15.9) | 14 (51.9) | |
PSAdt (months), median ± (IQRs) | 6.1 (3.3–13.4) | 7.6 (3.7–16.7) | 3.8 (2.1–6) | < 0.001 |
PSAdt (months), n (%) | < 0.01 | |||
≤ 6 months | 56 (48.7) | 35 (39.8) | 21 (77.8) | |
> 6 months | 59 (51.3) | 53 (60.2) | 6 (22.2) | |