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Table 5 CT features comparison of multiple primary lung adenocarcinomas in different EGFR and ALK status (in pre-lesions)

From: CT features associated with EGFR mutations and ALK positivity in patients with multiple primary lung adenocarcinomas

CT features

EGFR+ (n = 62)

EGFR-(n = 73)

Total

P

ALK+ (n = 23)

ALK-(n = 112)

Total

P

Diameter (cm)a

1.7 ± 1.3

1.7 ± 1.6

1.7 ± 1.5

0.835

2.1 ± 2.1

1.6 ± 1.3

1.7 ± 1.5

0.237

Type

   

0.118

   

0.305

 Central

15(24)

10(14)

25(19)

 

6(26)

19(17)

25(19)

 

 Peripheral

47(76)

63(86)

110(81)

 

17(74)

93(83)

110(81)

 

Distribution

   

0.537

   

0.007*

 left upper lobe

13(21)

12(16)

25(19)

 

5(22)

20(18)

25(19)

 

 left lower lobe

12(19)

8(11)

20(15)

 

1(4)

19(17)

20(15)

 

 right upper lobe

17(27)

21(29)

38(28)

 

3(13)

35(31)

38(28)

 

 right middle lobe

8(13)

12(16)

20(15)

 

2(9)

18(16)

20(15)

 

 right lower lobe

12(19)

20(27)

32(23)

 

12(52)

20(18)

32(23)

 

Texture

   

0.002*,b

   

0.005*,b

 Solid

35(56)

59(81)

94(70)

 

22(96)

72(64)

94(70)

 

 GGO

27(44)

14(19)

41(30)

 

1(4)

40(36)

41(30)

 

  pGGO

4(6)

10(14)

14(10)

0.514c

0(0)

14(13)

14(10)

0.070c

  mGGO

23(37)

4(5)

27(20)

<0.001*,d,e

1(4)

26(23)

27(20)

0.021*d,e

Shape

   

0.259

   

0.341

 lobulated

20(32)

31(41)

51(38)

 

7(30)

46(41)

51(38)

 

 others

42(68)

42(58)

84(62)

 

16(70)

66(59)

84(62)

 

 Spiculate

25(40)

28(37)

53(39)

0.816

14(61)

39(35)

53(39)

0.134

Margin definition

   

1.000

   

0.453

 well-defined

18(29)

21(29)

39(29)

 

5(22)

34(30)

39(29)

 

 poor-defined

44(71)

52(71)

96(71)

 

18(78)

78(70)

96(71)

 

Air bronchogram

28(45)

18(25)

46(34)

0.012*

5(22)

41(37)

46(34)

0.171

Heterogeneity

24(39)

35(48)

49(36)

0.358

12(52)

47(42)

49(36)

0.369

Pleural attachment

28(45)

25(34)

53(39)

0.196

8(35)

45(40)

53(39)

0.815

Cavitation

3(5)

2(3)

5(4)

1.000

3(13)

2(2)

5(4)

1.000

Bubble-like lucency

17(27)

15(21)

32(24)

0.349

5(22)

27(24)

32(24)

1.000

Calcifications

5(8)

3(4)

8(6)

0.332

2(9)

6(5)

8(6)

1.000

Necrosis

25(40)

23(32)

48(36)

0.286

6(26)

42(38)

48(36)

0.298

Vascular convergence

15(24)

27(37)

42(31)

0.110

6(26)

36(32)

42(31)

0.298

Peripheral fibrosis

22(35)

21(29)

43(32)

0.404

7(30)

36(32)

43(32)

0.873

Peripheral emphysema

14(23)

20(27)

34(25)

0.521

5(22)

2(2)

34(25)

0.676

Enhancement degree

   

0.807

   

0.559

 mild

34(69)

41(73)

75(71)

 

16(70)

59(70)

75(71)

 

 moderate

12(24)

13(23)

25(24)

 

6(26)

19(23)

25(24)

 

 marked

3(7)

2(4)

5(5)

 

1(4)

4(7)

5(5)

 
  1. * P values<0.05
  2. a The maximum diameter of the lesion (in centimeters) evaluated on the multiplanar reconstructions (MPRs) with a soft tissue window;
  3. b Comparison between solid and GGO
  4. c Comparison between solid and pGGO
  5. d Comparison between solid and mGGO
  6. e Comparison between pGGO and mGGO
  7. EGFR+ epidermal growth factor receptor mutation, EGFR- EGFR wild-type group, GGO ground-glass opacity, pGGO pure ground-glass opacity, mGGO mix ground-glass opacity
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