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Table 5 CT features comparison of multiple primary lung adenocarcinomas in different EGFR and ALK status (in pre-lesions)

From: CT features associated with EGFR mutations and ALK positivity in patients with multiple primary lung adenocarcinomas

CT features EGFR+ (n = 62) EGFR-(n = 73) Total P ALK+ (n = 23) ALK-(n = 112) Total P
Diameter (cm)a 1.7 ± 1.3 1.7 ± 1.6 1.7 ± 1.5 0.835 2.1 ± 2.1 1.6 ± 1.3 1.7 ± 1.5 0.237
Type     0.118     0.305
 Central 15(24) 10(14) 25(19)   6(26) 19(17) 25(19)  
 Peripheral 47(76) 63(86) 110(81)   17(74) 93(83) 110(81)  
Distribution     0.537     0.007*
 left upper lobe 13(21) 12(16) 25(19)   5(22) 20(18) 25(19)  
 left lower lobe 12(19) 8(11) 20(15)   1(4) 19(17) 20(15)  
 right upper lobe 17(27) 21(29) 38(28)   3(13) 35(31) 38(28)  
 right middle lobe 8(13) 12(16) 20(15)   2(9) 18(16) 20(15)  
 right lower lobe 12(19) 20(27) 32(23)   12(52) 20(18) 32(23)  
Texture     0.002*,b     0.005*,b
 Solid 35(56) 59(81) 94(70)   22(96) 72(64) 94(70)  
 GGO 27(44) 14(19) 41(30)   1(4) 40(36) 41(30)  
  pGGO 4(6) 10(14) 14(10) 0.514c 0(0) 14(13) 14(10) 0.070c
  mGGO 23(37) 4(5) 27(20) <0.001*,d,e 1(4) 26(23) 27(20) 0.021*d,e
Shape     0.259     0.341
 lobulated 20(32) 31(41) 51(38)   7(30) 46(41) 51(38)  
 others 42(68) 42(58) 84(62)   16(70) 66(59) 84(62)  
 Spiculate 25(40) 28(37) 53(39) 0.816 14(61) 39(35) 53(39) 0.134
Margin definition     1.000     0.453
 well-defined 18(29) 21(29) 39(29)   5(22) 34(30) 39(29)  
 poor-defined 44(71) 52(71) 96(71)   18(78) 78(70) 96(71)  
Air bronchogram 28(45) 18(25) 46(34) 0.012* 5(22) 41(37) 46(34) 0.171
Heterogeneity 24(39) 35(48) 49(36) 0.358 12(52) 47(42) 49(36) 0.369
Pleural attachment 28(45) 25(34) 53(39) 0.196 8(35) 45(40) 53(39) 0.815
Cavitation 3(5) 2(3) 5(4) 1.000 3(13) 2(2) 5(4) 1.000
Bubble-like lucency 17(27) 15(21) 32(24) 0.349 5(22) 27(24) 32(24) 1.000
Calcifications 5(8) 3(4) 8(6) 0.332 2(9) 6(5) 8(6) 1.000
Necrosis 25(40) 23(32) 48(36) 0.286 6(26) 42(38) 48(36) 0.298
Vascular convergence 15(24) 27(37) 42(31) 0.110 6(26) 36(32) 42(31) 0.298
Peripheral fibrosis 22(35) 21(29) 43(32) 0.404 7(30) 36(32) 43(32) 0.873
Peripheral emphysema 14(23) 20(27) 34(25) 0.521 5(22) 2(2) 34(25) 0.676
Enhancement degree     0.807     0.559
 mild 34(69) 41(73) 75(71)   16(70) 59(70) 75(71)  
 moderate 12(24) 13(23) 25(24)   6(26) 19(23) 25(24)  
 marked 3(7) 2(4) 5(5)   1(4) 4(7) 5(5)  
  1. * P values<0.05
  2. a The maximum diameter of the lesion (in centimeters) evaluated on the multiplanar reconstructions (MPRs) with a soft tissue window;
  3. b Comparison between solid and GGO
  4. c Comparison between solid and pGGO
  5. d Comparison between solid and mGGO
  6. e Comparison between pGGO and mGGO
  7. EGFR+ epidermal growth factor receptor mutation, EGFR- EGFR wild-type group, GGO ground-glass opacity, pGGO pure ground-glass opacity, mGGO mix ground-glass opacity