Table 3 Pathology comparison of of multiple primary lung adenocarcinomas in different EGFR and ALK status (in pre-lesions)
Variable | EGFR+ (n = 62) | EGFR- (n = 73) | Total | P | ALK+ (n = 23) | ALK-(n = 112) | Total | P |
|---|---|---|---|---|---|---|---|---|
TNM stagea | Â | Â | Â | 0.312 | Â | Â | Â | 0.160 |
 I-II | 22(35) | 20(27) | 42(31) |  | 10(43) | 32(29) | 42(31) |  |
 III-IV | 40(65) | 53(73) | 93(29) |  | 13(57) | 80(71) | 93(68) |  |
Histological subtype | ||||||||
 Lepidic predominantb | 15(24) | 10(14) | 25(19) | 0.118 | 3(13) | 22(20) | 25(19) | 0.567 |
 other subtype1c | 47(76) | 63(86) | 110(81) |  | 20(87) | 90(80) | 110(81) |  |
  Solid or Mucinous | 5(8) | 11(15) | 16(12) | 0.210 | 8(35) | 8(7) | 16(12) | <0.001* |
 other subtype 2d | 57(92) | 61(84) | 118(88) |  | 15(65) | 103(93) | 118(88) |  |
  Acinar | 30(48) | 29(40) | 59(43) |  | 7(30) | 53(47) | 59(44) |  |
  Papillary | 8(13) | 21(29) | 29(21) |  | 5(22) | 24(21) | 29(21) |  |
  Solid | 3(5) | 8(11) | 11(8) |  | 6(26) | 5(4) | 11(8) |  |
  Mucinous | 1(2) | 3(4) | 4(3) |  | 2(9) | 2(2) | 4(3) |  |
  Micropapillary | 1(2) | 2(3) | 3(2) |  | 2(9) | 1(1) | 3(2) |  |
  Sieve | 2(3) | 2(3) | 4(3) |  | 0(0) | 4(3) | 4(3) |  |
 Pleural invasion | 25(40) | 27(37) | 52(39) | 0.691 | 9(39) | 41(37) | 52(39) | 0.819 |