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Fig. 3 | Cancer Imaging

Fig. 3

From: CT features associated with EGFR mutations and ALK positivity in patients with multiple primary lung adenocarcinomas

Fig. 3

A 56-year-old female with two concurrent primary lung adenocarcinomas, one in the left lower lobe (lesion A) (a) and one in the left upper lobe (lesion B) (b). Lesion A was a well to moderately differentiated adenocarcinoma and appeared as a mixed GGO nodule on CT. Lesion B was an adenocarcinoma and appeared as a solid mass with a lobulated border on CT. Haematoxylin and eosin (H&E) staining showed (c) papillary patterns for T1 but (d) solid and cribriform predominant patterns for T2. ARMS-PCR analysis identified an EGFR mutation in (e) T1 but not in (f) T2. IHC and fluorescence in situ hybridization (FISH) showed positive and negative results, respectively, for ALK in T1 but positive results in T2

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