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Table 6 Association of quantitative imaging features for CT and MRI with time to recurrence (TTR) and overall survival (OS) in patients with ICC. The hazard ratios (HR) and lower and upper limits of a 95% confidence interval from Cox regression are shown, when available

From: Outcomes assessment in intrahepatic cholangiocarcinoma using qualitative and quantitative imaging features

 

Feature

TTR

OS

p*

p**

HR

95% CI

p*

p**

HR

95% CI

CT

Energy

0.096

0.065

0.51

0.23–1.15

0.345

0.293

0.65

0.27–1.59

Contrast

0.713

0.980

1.06

0.77–1.46

0.305

0.278

1.21

0.84–1.74

Correlation

0.864

0.875

0.97

0.71–1.34

0.367

0.335

0.85

0.59–1.22

Variance

0.208

0.185

0.83

0.63–1.11

0.184

0.243

0.80

0.58–1.11

Homogeneity

0.404

0.496

0.87

0.62–1.22

0.385

0.378

0.83

0.54–1.27

Sum Average

0.045

0.021

0.70

0.49–0.99

0.147

0.132

0.72

0.46–1.12

Sum Variance

0.124

0.126

0.79

0.58–1.07

0.136

0.100

0.76

0.53–1.09

Sum Entropy

0.153

0.089

1.43

0.88–2.33

0.551

0.567

1.19

0.68–2.06

Entropy

0.038

0.042

1.59

1.03–2.45

0.292

0.247

1.32

0.79–2.21

Difference Variance

0.713

0.980

1.06

0.77–1.46

0.305

0.278

1.21

0.84–1.74

Difference Entropy

0.387

0.527

1.15

0.83–1.60

0.304

0.292

1.23

0.83–1.83

Information Measure of Correlation 1

0.064

0.075

1.49

0.98–2.28

0.421

0.331

1.23

0.75–2.02

Information Measure of Correlation 2

0.047

0.132

0.73

0.53–1.00

0.187

0.209

0.78

0.54–1.13

Maximal Correlation Coefficient

0.165

0.169

0.77

0.53–1.11

0.213

0.174

0.74

0.47–1.18

Enhancement Ratio (AP)

0.104

0.146

0.43

0.16–1.2

0.361

0.320

0.63

0.23–1.70

Enhancement Ratio (PVP)

0.238

0.247

0.64

0.30–1.4

0.187

0.127

0.57

0.25–1.30

MRI

Energy

0.922

0.909

1.02

0.66–1.59

0.520

0.543

0.73

0.29–1.88

Contrast

0.133

0.102

0.63

0.34–1.15

0.097

0.101

0.48

0.20–1.15

Correlation

0.129

0.097

1.58

0.88–2.86

0.087

0.091

2.05

0.89–4.74

Variance

0.601

0.641

0.89

0.58–1.37

0.654

0.750

0.87

0.48–1.59

Homogeneity

0.011

0.006

1.79

1.13–2.84

0.171

0.191

1.46

0.84–2.54

Sum Average

0.277

0.194

0.79

0.51–1.22

0.703

0.766

0.90

0.52–1.56

Sum Variance

0.629

0.584

0.90

0.60–1.37

0.838

0.877

0.94

0.54–1.65

Sum Entropy

0.240

0.192

1.43

0.78–2.62

0.354

0.465

1.48

0.65–3.39

Entropy

0.323

0.322

1.28

0.79–2.08

0.186

0.199

1.60

0.80–3.22

Difference Variance

0.133

0.102

0.63

0.35–1.15

0.097

0.101

0.48

0.20–1.15

Difference Entropy

0.015

0.013

0.58

0.37–0.91

0.140

0.154

0.67

0.38–1.16

Information Measure of Correlation 1

0.420

0.524

1.21

0.76–1.92

0.059

0.038

1.87

0.97–3.62

Information Measure of Correlation 2

0.736

0.985

0.93

0.61–1.43

0.068

0.050

0.62

0.36–1.05

Maximal Correlation Coefficient

0.464

0.642

1.15

0.79–1.65

0.621

0.586

1.15

0.67–1.97

ADCMean

0.042

0.058

NA

NA

0.309

0.289

NA

NA

ADCMin

0.476

0.504

NA

NA

0.005

0.015

NA

NA

Enhancement Ratio (AP)

0.040

0.024

0.34

0.12–1.00

0.476

0.569

0.64

0.19–2.2

Enhancement Ratio (EP)

0.439

0.232

0.69

0.26–1.80

0.536

0.688

0.70

0.22–2.2

Enhancement Ratio (HBP)

0.117

0.119

NA

NA

0.522

0.495

NA

NA

Enhancement Ratio (PVP)

0.069

0.058

0.42

0.17–1.10

0.226

0.318

0.52

0.18–1.50

  1. Footnote: *p-values from the log-rank test, **p-values from generalized Wilcoxon tests
  2. Significant results are bolded