Table 5 Association of qualitative imaging features for CT and MRI provided by two independent observers with time to recurrence (TTR) and overall survival (OS) in patients with ICC. The hazard ratios (HR) and lower and upper limits of a 95% confidence interval from Cox regression are shown

CT

Biliary obstruction

1.2

0.62–2.33

0.593

0.947

2.22

1.14–4.36

0.017

0.075

Capsular retraction

1.11

0.57–2.18

0.758

0.631

1.03

0.50–2.10

0.938

0.791

Enhancement pattern

1.44

0.50–4.11

0.498

0.458

1.72

0.66–4.49

0.264

0.202

Satellite lesions

2.35

1.16–4.76

0.015

0.008

3.27

1.57–6.79

0.001

< 0.001

Vascular involvement

2.05

1.04–4.06

0.035

0.085

1.77

0.92–3.42

0.083

0.122

MRI

DWI Appearance

1.26

0.31–5.09

0.742

0.603

2.05

0.54–7.73

0.281

0.148

Biliary obstruction

1.64

0.65–4.15

0.288

0.338

1.88

0.75–4.75

0.174

0.122

Capsular retraction

0.75

0.30–1.88

0.537

0.498

0.61

0.18–2.13

0.437

0.321

Enhancement pattern

0.55

0.13–2.38

0.414

0.677

2.04

0.66–6.27

0.206

0.196

Signal on HBP

1.01

0.83–1.23

0.925

0.888

1.04

0.85–1.26

0.727

0.718

Satellite lesions

8.3

2.60–26.52

< 0.001

< 0.001

2.24

0.64–7.91

0.198

0.163

Vascular involvement

3.79

1.46–9.84

0.003

0.005

4.17

1.48–11.80

0.004

0.004

Feature

HR

95% CI

p*

p**

HR

95% CI

p*

p**

CT

Biliary obstruction

0.74

0.35–1.57

0.427

0.471

0.99

0.46–2.13

0.981

0.9

Capsular retraction

0.7

0.33–1.52

0.366

0.327

0.81

0.34–1.92

0.626

0.47

Enhancement pattern

1.41

0.32–6.29

0.654

0.783

1.38

0.31–6.20

0.673

0.656

Satellite lesions

1.86

0.85–4.07

0.113

0.315

2.13

0.96–4.70

0.056

0.117

Vascular involvement

1.18

0.54–2.55

0.68

0.886

0.73

0.33–1.61

0.436

0.702

MRI

DWI Appearance

1.41

0.23–8.60

0.709

0.335

1.93

0.32–11.62

0.464

0.166

Biliary obstruction

1.04

0.33–3.27

0.953

0.72

1.98

0.63–6.26

0.234

0.617

Capsular retraction

1.09

0.35–3.39

0.88

0.622

0.89

0.19–4.07

0.879

0.784

Enhancement pattern

1.86

0.50–6.90

0.346

0.186

4.69

1.12–19.67

0.021

0.028

Signal on HBP

1.33

0.88–2.00

0.142

0.085

1.36

0.90–2.04

0.111

0.064

Satellite lesions

3.32

0.99–11.13

0.039

0.255

3.47

0.89–13.53

0.056

0.327

Vascular involvement

1.93

0.62–6.02

0.252

0.66

2.82

0.89–8.89

0.065

0.126