Table 4 Results from logistic regression analysis of qualitative imaging features as predictors of pathologic grade and AJCC tumor stage. AUC, odds ratio (OR) and 95% confidence interval for the OR for the effect of each CT and MRI qualitative imaging feature derived by each observer on each binary outcome are shown

Outcome

Modality

Feature

AUC

OR

95% CI

P

AUC

OR

95% CI

P

Tumor Grade (G2 vs. G3)

CT

Biliary Obstruction

0.50

0.99

0.32–3.01

0.982

0.59

2.02

0.64–6.33

0.228

Capsular Retraction

0.63

0.33

0.10–1.09

0.068

0.63

0.31

0.09–1.06

0.061

Enhancement Pattern

0.57

5.00

0.54–46.34

0.157

0.55

2.39

0.4213.67

0.329

Satellite Lesions

0.58

2.37

0.62–9.09

0.207

0.54

1.66

0.42–6.61

0.470

Vascular involvement

0.53

0.79

0.24–2.60

0.697

0.53

0.76

0.25–2.38

0.643

MRI

DWI Appearance

0.58

0.50

0.07–3.55

0.488

0.53

0.75

0.11–5.24

0.772

Biliary Obstruction

0.68

5.00

1.15–21.80

0.032

0.65

3.94

0.91–17.01

0.066

Capsular Retraction

0.60

2.25

0.57–8.82

0.245

0.52

0.75

0.14–3.98

0.736

Enhancement Pattern

0.53

1.54

0.29–8.18

0.613

0.50

1.07

0.18–6.22

0.939

Hepatobiliary Phase

0.55

0.64

0.15–2.72

0.546

0.57

0.55

0.13–2.26

0.406

Satellite Lesions

0.53

1.54

0.29–8.18

0.613

0.53

1.71

0.25–11.78

0.584

Vascular involvement

0.51

1.09

0.27–4.41

0.903

0.54

1.46

0.32–6.70

0.628

AJCC Stage (Stage I-II vs stage III)

CT

Biliary Obstruction

0.70

5.38

1.61–17.97

0.006

0.73

7.18

2.10–24.57

0.002

Capsular Retraction

0.53

0.79

0.26–2.42

0.686

0.56

0.58

0.17–1.91

0.368

Enhancement Pattern

0.59

7.78

0.84–72.11

0.071

0.57

3.75

0.65–21.46

0.138

Satellite Lesions

0.65

4.81

1.26–18.35

0.022

0.60

3.33

0.86–12.99

0.083

Vascular involvement

0.64

3.51

1.04–11.84

0.043

0.68

4.89

1.48–16.13

0.009

MRI

DWI Appearance

0.56

1.67

0.21–13.22

0.629

0.70

5.33

0.62–45.99

0.128

Biliary Obstruction

0.66

3.86

0.94–15.86

0.061

0.66

3.86

0.94–15.86

0.061

Capsular Retraction

0.56

0.60

0.16–2.29

0.455

0.56

0.43

0.07–2.58

0.355

Enhancement Pattern

0.55

1.89

0.36–10.03

0.455

0.58

3.00

0.47–19.04

0.244

Hepatobiliary Phase

0.66

5.32

0.94–29.99

0.058

0.63

3.55

0.76–16.43

0.106

Satellite Lesions

0.61

4.09

0.67–24.83

0.126

0.60

6.33

0.63–63.64

0.117

Vascular involvement

0.63

3.00

0.73–12.27

0.126

0.73

19.00

2.03–177.93

0.010