Fig. 3

MRI texture feature of difference entropy found to be a significant predictor of TTR on univariable analysis. Top row (a, b): 54-year-old female with moderately differentiated ICC in segment 4 (AJCC stage 1). T1-weighted post-contrast MR image obtained during portal venous phase (a, arrow) with an overlying difference entropy texture map (b, arrow). This patient’s ICC difference entropy parameter was calculated to be 2.16 (scale 0–3, blue-red), with corresponding TTR of 825 days. Bottom row (c, d): 56-year-old female with poorly differentiated ICC (AJCC stage 3) in segment 4/8 on T1-weighted post-contrast MR image obtained during portal venous phase (c, arrow) and with an overlying difference entropy texture map (d, arrow). This patient’s ICC difference entropy parameter was calculated to be 1.22 (scale 0–3, blue-red) with corresponding TTR of 456 days. Color scale bar is shown on the right