Fig. 1

A flow chart depicts the different experiments and experimental groups (a) and provides an overview of the study design. An initial experiment compared the survival of animals treated with the B20 anti-VEGF-antibody and untreated controls. Survival analysis was performed according to the Kaplan-Meier product limit method and a survival curve is shown (b). Treated animals (black line) survived significantly longer than untreated controls (dotted line; median survival with and without treatment 24 and 10 days; p = 0.0011)