Table 2 Univariate Cox analysis of clinicopathological characteristics
Parameters | Cut-off value | Training cohort | Validation cohort | ||||
|---|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | ||
Age (year) | < 60 vs. ≥ 60 | 2.40 | 0.75–7.65 | 0.139 | 1.03 | 0.95–1.10 | 0.537 |
Gender | Female vs. Male | 0.30 | 0.04–2.27 | 0.242 | 0.46 | 0.08–4.06 | 0.565 |
Tumor location | Glottic vs. Non-glottic | 5.86 | 1.96–17.51 | 0.002 | 1.67 | 0.31–9.14 | 0.553 |
T classification | T1-T2 vs. T3-T4 | 2.06 | 0.72–5.96 | 0.178 | 1.90 | 0.38–9.41 | 0.432 |
N classification | N0 vs. N1-N2 | 2.64 | 0.88–7.88 | 0.082 | 4.50 | 0.82–14.76 | 0.084 |
Cancer stage | I-II vs. III-IV | 2.56 | 1.03–6.49 | 0.042 | 3.21 | 0.76–7.53 | 0.178 |
Histological grade | Well-moderate vs. Poor | 2.56 | 0.88–7.38 | 0.092 | 1.05 | 0.49–3.58 | 0.692 |
Laryngectomy | Partial vs. Total | 7.34 | 2.43–20.34 | < 0.001 | 2.38 | 1.02–8.25 | 0.048 |
Adjuvant therapy | No vs. Yes | 0.91 | 0.29–2.90 | 0.871 | 2.29 | 0.46–11.35 | 0.311 |