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Table 2 Results from the Analysis of different brain ROIs

From: Distribution of brain metastases: low-risk metastasis areas may be avoided when treating with whole-brain radiotherapy

Location of metastasis

N = 192 patients

N = 991 metastases

Structure Volume mean ± SD (VA/ V total)cm3

P valueb

Temporal lobe

51 (26.6%)

95 (9.6%)

192.3 ± 9.7 (16.1%)

< 0.001

 Left

34 (17.7%)

47 (4.7%)

96.4 ± 4.9 (8.1%)

 

 Right

35 (18.2%)

48 (4.8%)

96.0 ± 5.0 (8.0%)

 

Frontal lobe

80 (41.7%)

170 (17.2%)

358.3 ± 12.8 (30.0%)

< 0.001

 Left

53 (27.6%)

82 (8.3%)

179.3 ± 6.0 (15.0%)

 

 Right

55 (28.6%)

88 (8.9%)

179.1 ± 7.1 (15.0%)

 

Parietal lobe

115 (59.9%)

314 (31.7%)

173.1 ± 15.5 (14.5%)

< 0.001

 Left

83 (43.2%)

168 (17.0%)

86.8 ± 7.3 (7.3%)

 

 Right

74 (38.5%)

146 (14.7%)

86.3 ± 8.3 (7.2%)

 

Occipital lobe

81 (42.2%)

215 (21.7%)

179.1 ± 9.0 (15.0%)

< 0.001

 Left

53 (27.6%)

100 (10.1%)

89.3 ± 4.7 (7.5%)

 

 Right

57 (29.7%)

115 (11.6%)

89.7 ± 4.4 (7.5%)

 

Cerebellum

71 (37.0%)

165 (16.6%)

128.4 ± 8.9 (10.7%)

< 0.001

 Left

47 (24.5%)

77 (7.8%)

59.3 ± 4.3 (5.0%)

 

 Right

42 (21.9%)

74 (7.5%)

59.3 ± 5.0 (5.0%)

 

 Vermis

12 (6.3%)

14 (1.4%)

9.8 ± 0.8 (0.8%)

 

Brainstem

9 (4.7%)

10 (1.0%)

24.5 ± 1.9 (2.0%)

< 0.02

 Left

5 (2.6%)

5 (0.5%)

 

 Right

5 (2.6%)

5 (0.5%)

 

Insular lobec

7 (3.6%)

8 (0.8%)

19.1 ± 2.0 (1.6%)

< 0.05

 Left

6 (3.1%)

6 (0.6%)

9.6 ± 1.1 (0.8%)

 

 Right

2 (1.0%)

2 (0.2%)

9.5 ± 1.0 (0.8%)

 

Diencephalon + Internal structurea

8 (4.2%)

8 (0.8%)

63.1 ± 8.1 (5.3%)

< 0.001

Corpus callosum

4 (2.1%)

4 (0.4%)

57.8 ± 7.0 (4.8%)

< 0.001

Pituitary

0

0

0.7 ± 0.1 (0.1%)

> 0.2

Brainstem+ Insular lobe+ Diencephalon Internal structurea + Corpus callosum + pituitary

25 (13.0)

30 (3%)

165.1 ± 9.7 (13.8%)

< 0.001

  1. ROIs regions of interest, VA volume of ROIA, Vtotal total volume of all 11 ROIs
  2. aInternal structure Include caudate nucleus, lentiform nucleus, inner capsule
  3. bBrain metastasis ratio vs Volume ratio
  4. cInsular lobe Include Insular cortex, external capsule, extreme capsule, claustrum