Table 1 Characteristics at time of diagnosis in patients with high-grade osteosarcoma

 Median (range)

16 (4.6–43)

14 (4–46)

0.3939

15 (8–39)

18 (7–44)

0.6123

  ≤ 15 y

27

45

13

12

  > 15 y

30

35

12

17

Gender

1

0.5852

 Male

34

47

14

13

 Female

23

33

11

16

Location of primary tumor

0.3447

0.8041

 Humerus

11

8

3

3

 Femur

27

45

14

17

 Tibia and fibula

17

20

8

8

 Radius and ulna

1

2

0

0

 Others

1

5

0

1

Stage at diagnosis

1

0.3062

 Localized

47

66

20

27

 Metastatic

10

14

5

2

Pathologic subtype

0.3055

0.332

 Osteoblastic

46

55

20

19

 Chondroblastic

3

13

1

5

 Fibroblastic

4

4

4

4

 Telangiectatic

3

5

0

1

 Others

1

3

0

0

Type of surgery

0.02487*

1

 Limb salvage

55

66

24

27

 Amputation

2

14

1

2

New pulmonary metastasis

1

0.9402

 Yes

2

4

1

0

 No

55

76

24

29

Chemotherapy regimens

0.7224

0.4406

 1MTX, DDP and ADM

42

58

17

22

 2MTX, IFO,DDP and ADM

12

15

8

6

 3MTX,IFO, DDP and ADM

3

7

0

1

 Radiomics score

4.4E-4(−1.1–0.72)

−0.55(−2.9–0.32)

2.1E-14

0.030(−0.58–0.71)

−0.31(−2.1–0.34)

2.4E-5