Table 5 Features based predictors that discriminate indolent grade cancer (Gleason = 6 Vs Benign) from benign a) univariate semantic predictors b) multivariable semantic predictors (up to 3 semantics) c) PIRADS based predictor
From: Radiological semantics discriminate clinically significant grade prostate cancer
|  | Features | Error | Sensitivity/Specificity | PPV/NPV | E [AUC],σ, [CI] |
|---|---|---|---|---|---|
A) Single Predictive Semantic: Gleason 6 Vs Benign || Samples: 110 (33 Vs 77) | |||||
 1 | F11:extraprostatic-extension-R | 0.279 | 0.058/1 | 0.34/0.71 | 0.586 (0.12) [0.307,0.822] |
 2 | F7:early-enhancement-R | 0.301 | 0/1 | 0/0.688 | 0.609 (0.1) [0.391,0.842] |
 3 | F4:ADC-intensity | 0.319 | 0.014/0.98 | 0.006/0.702 | 0.614 (0.119) [0.348,0.928] |
 4 | F6:enhacement-degree | 0.31 | 0.026/0.982 | 0.049/0.706 | 0.562 (0.126) [0.328,0.815] |
 5 | F3:T2-intensity | 0.308 | 0/1 | 0/0.701 | 0.546 (0.103) [0.35,0.775] |
B) Multivariable Semantic Predictor: GS 6 Vs Benign || Samples 110 (33 Vs 77) | |||||
 1 | F5:homogeneity-R;F7:early-enhancement-R:F11:extraprostatic-extension-R | 0.287 | 0.204/0.954 | 0.571/0.735 | 0.627 (0.137), [0.347,0.931] |
 2 | F4:ADC-intensity;F7:early-enhancement-R:F11:extraprostatic-extension-R | 0.295 | 0.156/0.954 | 0.514/0.725 | 0.632 (0.114), [0.385,0.822] |
 3 | F3:T2-intensity;F7:early-enhancement-R:F11:extraprostatic-extension-R | 0.305 | 0.157/0.947 | 0.404/0.743 | 0.624 (0.136), [0.406,0.909] |
 4 | F5:homogeneity-R;F7:early-enhancement-R:F11:extraprostatic-extension-R | 0.287 | 0.204/0.954 | 0.571/0.735 | 0.627 (0.137), [0.347,0.931] |
C) PIRADS as a Predictor (GS 6 Vs Benign) || Samples: 110 (33 Vs 77) | |||||
 1 | PIRADS(≥ 3) | 0.544 | 0.878/0.271 | 0.344/0.839 | 0.575 (0.083) [0.358,0.744] |
 2 | PIRADS(≥ 4) | 0.44 | 0.769/0.468 | 0.384/0.823 | 0.618 (0.094) [0.393,0.775] |
 3 | PIRADS(≥ 5) | 0.286 | 0.102/0.978 | 0.449/0.716 | 0.54 (0.062) [0.46,0.689] |