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Table 2 Detailed semantic descriptors for prostate cancer a) broad categories b) feature description

From: Radiological semantics discriminate clinically significant grade prostate cancer

a. Feature categories
Prostate Semantics
  Categories Features Description
1 Semantics 16 Shape, border, lymphadenopathy
(F1:shape, F2:border,
F3:T2 intensity, F4:ADC intensity,
F5:homogeneity, F6:enhacement degree, F7:early enhancement,
F8:enhanced homogenicity,
F9:capsule, F10:cyst,
F11:extraprostatic extension,
F12:seminal vesicles, F13:distal sphincter, F14:bladder neck,
F15:lymph adenopathy, F16:BPH)
2 PIRADS 1 Over-all
b. Semantic scoring sheet for prostate nodules (Note: level 0 to k was mapped to 1 to k + 1 with fixed offset).
Characteristics   Definition Scoring definition
lesion Location section central location: nodule located in the central zone or transitional zone
peripheral location: tumor located in the peripheral zone
1 = central gland
2 = peripheral zone
3 = both
Lateral The prostate is divided into right/left on axial sections by a vertical line drawn through the center 1 = L
2 = R
3 = Both
Size maximum transverse diameter longest nodule width measured on axial images  
maximum longitudinal diameter Longest nodule length measured on sagittal images  
maximum AP diameter Longest nodule anterior-posterior diameter measuring on axial images  
Shape the overall shape of roundness 1 = round/ oval
2 = irregular
3 = amorphous
Margin Border definition well or ill-defined border 1 = well defined
2 = everything else between 1 and 3
3 = poorly defined
  Capsule Whether capsule could be found for the nodule 0 = absence
1 = presence
intensity rT2 The intensity of nodule on T2WI compared with the intensity of normal peripheral zone T2WI nodule/T2WI peri
rADC The ADC value of nodule compared with that of normal peripheral zone ADC nodule /ADC peri
T2 intensity T2 signal intensity of the lesion was compared to surrounding tissues and defined as “marked hypointensity” if the lesion expressed similar signal intensity than back muscles, “hypointensity” if the lesion was brighter than back muscles but darker than adjacent prostate tissue, “iso” if the lesion was similar to adjacent prostate tissue, and “hyperintensity” if the lesion was brighter than the adjacent prostate tissue. 1 = hyperintensity
2 = iso-intensity
3 = hypointensity
4 = marked hypointensity
Homogeneity on T2WI   0 = no
1 = yes
Cyst The presence or absence of cyst in the nodule 0 = absence
1 = presence
ADC intensity   1 = hyperintensity
2 = iso-intensity
3 = hypointensity
4 = marked hypointensity
Enhancement degree   1 = no enhancement
2 = slight enhancement
3 = moderate enhancement
4 = obvious enhancement
Early enhancement   0 = absence
1 = presence
Enhancement homogeneity Nodule homogeneity after enhancement 0 = absence
1 = presence
Extraprostatic extension Extracapsular extension   0 = No signs of ECE
1 = Capsular abutment
3 = Capsular irregularity, retraction or thickening
4 = Neurovascular bundle thickening
4 = Bulge or loss of capsule
5 = Measurable extracapsular disease
Seminal vesicle Whether seminal vesicle is invaded by prostate tumor or not 0 = No signs of invasion
1 = Expansion
2 = Low T2 signal
3 = Filling in of angle
4 = Enhancement and impeded diffusion
Bladder neck Whether bladder neck is invaded by prostate tumor or not 2 = Adjacent tumor
3 = Loss of low T2 signal in bladder muscle
4 = Abnormal enhancement extending into bladder neck
   Distal sphincter Whether distal sphincter is invaded by prostate tumor or not 2 = Adjacent tumor
3 = effacement of low signal sphincter muscle
4 = Abnormal enhancement extending into sphincter
prostate volume (maximum AP diameter) × (maximum transverse diameter) × (maximum longitudinal diameter) × 0.52  
  Benign prostate hyperplasia The AP/transverse/ longitudinal diameter of prostate larger than 5 cm 0 = absence
1 = presence
other Lymphadenopathy The short axis of lymph node larger than 8 mm 0 = absence
1 = presence