Table 1 Characteristics of included studies
Author | Year | Recruitment period | Design | Disease | Treatment | Total sample | Median age, year | Tumor stage (AJCC, I/II/III/IV) | Male, n (%) | Adjuvant therapy, n (%) |
|---|---|---|---|---|---|---|---|---|---|---|
Yang, J. | 2019 | 2011–2017 | Retrospective | CRC | Surgery | 417 | 57.9 | 80/190/149/0 | 251 (60) | – |
Hopkins, J. J. | 2019 | 2007–2009 | Retrospective | CRC | Surgery | 968 | 65.8 | 100/374/494/0 | 589 (61) | 503 (52) |
van Vugt, J. L. A. | 2018 | 2007–2013 | Retrospective | CRC | Surgery | 816 | – | 255/293/269 | 440 (54) | 158 (19) |
van der Kroft, G. | 2018 | 2012–2013 | Retrospective | CRC | Surgery | 63 | – | 18/13/20/12 | 39 (62) | – |
Mosk, C. A. | 2018 | 2013–2015 | Retrospective | CRC | Surgery | 251 | 76 | – | 141 (56) | 26 (10) |
Mauricio, S. F. | 2018 | 2013–2016 | Retrospective | CRC | Surgery | 84 | 61.6 | 36/48 a | 39 (46) | 51 (61) |
Martin, L. | 2018 | 2013–2015 | Retrospective | CRC | Surgery | 210 | 66.6 | 385/713/887/109 | 1270 (60) | – |
Chen, W. Z. | 2018 | 2014–2017 | Retrospective | CRC | Surgery | 376 | 64.3 | 65/155/145/11 | 228 (61) | – |
Feliciano, E. M. C. | 2017 | 2006–2011 | Prospective | CRC | Surgery | 247 | 63 | 690/806/956/0 | 1251 (51) | – |
Black, D. | 2017 | 2006–2014 | Retrospective | CRC | Surgery | 339 |  | 58/153/128/0 | 181 (53) | 66 (19) |
Ouchi, A. | 2016 | 2012–2015 | Retrospective | CRC | Surgery | 60 | 69 | 42/18 a | 35 (58) | – |
Malietzis, G. | 2016 | 2006–2013 | Retrospective | CRC | Surgery | 805 | 69 | 189/265/267/84 | 472 (59) | 182 (23) |
Reisinger, K. W. | 2015 | 2010–2012 | Retrospective | CRC | Surgery | 310 | – | – | 155 (50) | – |
Park, B. K. | 2015 | 2005–2012 | Retrospective | CRC | Surgery | 543 | – | 185/314 a | 311 (57) | 51 (9) |
Miyamoto, Y. | 2015 | 2005–2010 | Retrospective | CRC | Surgery | 220 | – | 77/84/59/0 |  | 54 (25) |
Huang, D. D. | 2015 | 2014–2015 | Retrospective | CRC | Surgery | 142 | 62 | – | 88 (62) | 5 (4) |
Lieffers, J. R. | 2012 | 2002–2006 | Retrospective | CRC | Surgery | 234 | 63 | 0/74/83/77 | 135 (58) | – |
Pedziwiatr, M. | 2016 | 2014–2015 | Retrospective | CRC | Surgery | 124 | 65.9 | 32/32/39/21 | 73 (59) | – |
Jones, K. I. | 2015 | 2011–2012 | Retrospective | CRC | Surgery | 100 | 68.6 | – | 60 (60) | – |
Guinan, E. M. | 2018 | 2014–2016 | Retrospective | EC | Surgery | 27 | – | – | – | 27 (100) |
Mayanagi, S. | 2017 | 2004–2013 | Prospective | EC | Surgery | 66 | 63.3 | 0/27/39/0 | 57 (86) | 66 (100) |
Elliott, J. A. | 2017 | 2010–2015 | Retrospective | EC | Surgery | 207 | 61.6 | – | 165 (80) | 207 (100) |
Black, D. | 2017 | 2006–2014 | Retrospective | EC | Surgery | 108 | – | 30/43/35/0 | 74 (69) | 65 (60) |
Nishigori, T. | 2016 | 2005–2014 | Retrospective | EC | Surgery | 199 | – | 33/99/63/6 | 164 (82) | – |
Grotenhuis, B. A. | 2016 | 2001–2012 | Retrospective | EC | Surgery | 120 | 62 | – | 88 (73) | 120 (100) |
Yip, C. | 2014 | NG | Retrospective | EC | Surgery | 35 | 63 | 0/10/23/2 | 30 (86) | 35 (100) |
Nakashima, Y. | 2018 | 2004–2014 | Retrospective | EC | Surgery | 341 | – | 38/46/55/33 | 289 (85) | – |
Paireder, M. | 2017 | 2006–2013 | Retrospective | EC | Surgery | 130 | 61.4 | 15/22/76/3 | 106 (82) | 130 (100) |
Tamandl, D. | 2016 | 2006–2013 | Retrospective | EC | Surgery | 200 | 63.9 | 45/33/95/4 | 151 (76) | – |
Harada, K. | 2016 | 2005–2011 | Retrospective | EC | Surgery | 325 | – | 129/45/128/23 | 298 (92) | – |
Tan, B. H. | 2015 | 2010–2012 | Retrospective | EC | Surgery | 89 | 65.8 | 21/27/41/0 | 67 (75) | 89 (100) |
Zhang, Y. | 2019 | 2015–2017 | Retrospective | GC | Surgery | 156 | 59.1 | 48/27/81/0 | 115 (74) | 35 (22) |
Zhang, W. T. | 2018 | 2014–2016 | Prospective | GC | Surgery | 636 | – | 203/140/293/0 | 478 (75) | – |
Wang, S. L. | 2018 | 2009–2013 | Retrospective | GC | Surgery | 859 | 64 | 239/193/427/0 | 672 (78) | – |
Park, H. S. | 2018 | 2006–2009 | Retrospective | GC | Surgery | 136 | 55 | 0/57/79/0 | 96 (71) | 63 (46) |
O’Brien, S. | 2018 | 2008–2014 | Retrospective | GC | Surgery | 56 | 68.4 | 18/13/18/0 | 41 (73) | 28 (50) |
Nishigori, T. | 2018 | 2005–2013 | Retrospective | GC | Surgery | 177 | – | 0/100/77/0 | 127 (72) | 127 (72) |
Mao, C. C. | 2018 | 2014–2016 | Prospective | GC | Surgery | 682 | 64.6 | – | 513 (75) | – |
Lin, J. | 2018 | 2015–2016 | Prospective | GC | Surgery | 670 | 65 | – | – | – |
Choi, M. H. | 2018 | 2007–2009 | Retrospective | GC | Surgery | 98 | – | – | – | – |
Beuran, M. | 2018 | 2014–2016 | Retrospective | GC | Surgery | 78 | – | 6/28/41/13 | – | – |
Zhou, C. J. | 2017 | 2014–2015 | Retrospective | GC | Surgery | 240 | 73 | 74/55/111/0 | 190 (79) | – |
Zheng, Z. F. | 2017 | 2009–2013 | Retrospective | GC | Surgery | 639 |  | – | 525 (82) | 408 (64) |
Lou, N. | 2017 | 2014–2015 | Retrospective | GC | Surgery | 206 | 64.1 | 80/45/81/0 | 161 (78) | – |
Kudou, K. | 2017 | 2005–2016 | Retrospective | GC | Surgery | 148 | – | – | – | – |
Huang, D. D. | 2017 | 2014–2015 | Retrospective | GC | Surgery | 470 | 65 | 163/103/204/0 | 364 (77) | – |
Zhuang, C. L. | 2016 | 2008–2013 | Retrospective | GC | Surgery | 937 | 64 | 271/219/447 | 730 (78) | – |
Wang, S. L. | 2016 | 2014–2015 | Prospective | GC | Surgery | 255 | 65.1 | 81/48/126/0 | 190 (75) | – |
Takeuchi, M. | 2016 | 2009–2015 | Retrospective | GC | Surgery | 75 | – | 25/16/28/6 | 57 (76) | 3 (4) |
Huang, D. D. | 2016 | 2014–2015 | Prospective | GC | Surgery | 173 | 72 | 53/40/80/0 | 135 (78) | – |
Tegels, J. J. | 2015 | 2005–2012 | Retrospective | GC | Surgery | 152 | 69.6 | 42/27/47/57 | 87 (57) | 71 (47) |
Li, X. T. | 2015 | 2005–2008 | Retrospective | GC | Surgery | 84 | 57 | 0/31/53/0 | 60 (71) | – |
Sakurai, K. | 2017 | 2007–2013 | Retrospective | GC | Surgery | 569 | 66.7 | 264/121/126/58 | 396 (70) | 91 (16) |
Chen, F. F. | 2016 | 2014–2016 | Prospective | GC | Surgery | 158 | 66.9 | 33/37/88/0 | 126 (80) | – |
Takeda, Y. | 2018 | 2004–2011 | Retrospective | RC | Surgery | 144 | – | 0/45/99/0 | 102 (71) | 63 (44) |
Park, S. E. | 2018 | 2005–2015 | Retrospective | RC | Surgery | 65 | 71 | 8/24/27/0 | 46 (71) | 65 (100) |
Choi, M. H. | 2018 | 2009–2013 | Retrospective | RC | Surgery | 188 | 61.3 | 0/34/154/0 | 117 (62) | 188 (100) |
Heus, C. | 2016 | 2006–2013 | Retrospective | RC | Surgery | 74 | 64 | – | 39 (53) | – |
Souza, B. U. | 2018 | 2015–2016 | Retrospective | CRC | All | 197 | 60.5 | 54/138 a | 112 (57) | – |
Kurk, S. A. | 2018 | NG | Prospective | CRC | AT | 450 | – | – | 285 (63) | n/a |
Chemama, S. | 2016 | 2008–2010 | Retrospective | CRC | AT | 97 | 53 | – | 37 (38) | n/a |
Blauwhoff-Buskermolen, S. | 2016 | 2011–2014 | Retrospective | CRC | AT | 67 | 66.4 | – | 42 (63) | n/a |
Barret, M. | 2014 | NG | Retrospective | CRC | AT | 51 | 65 | – | 38 (75) | n/a |
Guiu, B. | 2010 | 2002–2008 | Retrospective | CRC | AT | 120 | – | – | 55 (46) | n/a |
Anandavadivelan, P. | 2016 | 2006–2012 | Retrospective | EC | AT | 72 | – | 2/20/50/0 | – | n/a |
Awad, S. | 2012 | NG | Retrospective | EC | AT | 47 | – | – | 34 (72) | n/a |
Sugiyama, K. | 2018 | 2013–2015 | Retrospective | GC | AT | 118 | 64 | – | 59 (50) | n/a |
Palmela, C. | 2017 | 2012–2014 | Retrospective | GC | AT | 47 | 68 | 0/5/42/0 | 32 (68) | n/a |
Mirkin, K. A. | 2017 | 2000–2015 | Retrospective | GC | AT | 41 | – | – | – | n/a |
Hayashi, N. | 2016 | 2009–2014 | Retrospective | GC | AT | 53 | – | – | – | n/a |
Nipp, R. D. | 2018 | 2011–2015 | Retrospective | GIC | AT | 103 | – | – | – | n/a |