Dual-energy spectral CT characteristics in surgically resected lung adenocarcinoma: comparison between Kirsten rat sarcoma viral oncogene mutations and epidermal growth factor receptor mutations

Table 3 Comparison between clinical and DESCT characteristics with KRAS and EGFR mutation status in solid lung adenocarcinoma

Characteristics	Total	KRAS	EGFR	P value
No. of patients	56	12	44
Age (y)^a	55.98 ± 10.37	58.75 ± 7.53	55.23 ± 10.97	0.301
Sex				0.149
Female	29 (51.8)	4 (33.3)	25 (56.8)
Male	27 (48.2)	8 (66.7)	19 (43.2)
Smoking				0.012
Never smoked	36 (64.3)	4 (33.3)	32 (72.7)
Smoker	20 (35.7)	8 (66.7)	12 (27.3)
Location				0.452
Central	2 (3.6)	0 (0.0)	2 (4.5)
Peripheral	54 (96.4)	12 (100.0)	42 (95.5)
T stage				0.148
T_1–2	52 (92.9)	10 (83.3)	42 (95.5)
T_3–4	4 (7.1)	2 (16.7)	2 (4.5)
N stage				0.158
N₀	32 (57.1)	9 (7.5)	23 (52.3)
N_1–2	24 (42.9)	3 (2.5)	21 (47.7)
Maximum diameter^b	3.15 ± 1.32	3.17 ± 1.38	3.14 ± 1.32	0.742
DESCT quantitative parameter
CT number at 70 keV^a	47.39 ± 23.04	31.52 ± 22.26	51.71 ± 21.51	0.006
Slope λ HU^b	1.71 ± 0.92	1.17 ± 0.77	1.85 ± 0.91	0.017
NIC^b	0.198 ± 0.12	0.14 ± 0.09	0.21 ± 0.12	0.013
NWC^b	0.989 ± 0.02	0.98 ± 0.02	0.99 ± 0.02	0.239
Effective Z^a	8.45 ± 0.43	8.17 ± 0.39	8.52 ± 0.41	0.010

Note. Values are mean ± standard deviation or number (percentage)
^aQuantitative data exhibited normal distribution and T test was applied
^bQuantitative data did not exhibit normal distribution and Mann-Whitney U test was applied
P < 0.05 indicates significant difference; Significant P values are in bold
NIC Normalized iodine concentration, NWC Normalized water concentration, Slope λ HU the slope of the spectral Hounsfield unit curve, Effective Z effective atomic number

ISSN: 1470-7330