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Fig. 5 | Cancer Imaging

Fig. 5

From: PET/CT-guided versus CT-guided percutaneous core biopsies in the diagnosis of bone tumors and tumor-like lesions: which is the better choice?

Fig. 5

A 45-year-old man with suspected primary bone malignancies of the right femur. a 18F-FDG PET/CT imaging shows uptake (SUVmax 22.7) in the bone lesion in the right femur (yellow arrow). The maximum intensity projection image also confirms the presence of the bone lesion (red arrow). b-c The intraprocedural axial noncontrast CT image (using bone windows) shows the biopsy needle targeted within the lesion (yellow arrow). The histopathologic biopsy results (d: hematoxylin and eosin, original magnification 40×, e: hematoxylin and eosin, original magnification 100×) confirmed the bone lesion as an osteosarcoma. Immunohistochemistry showed cancer cells: S-100 (−), MDM-2 (−), SATB2 (+), P16 (−), CDK4 (weak +), CK (−), VIMENTIN (+), LCA (−), Desmin (−), MyoD1 (−), and Ki-67 (Li: 50%). Finally, the surgical histopathology results (f: hematoxylin and eosin, original magnification 40×, g: hematoxylin and eosin, original magnification 100×) of the bone lesion confirmed the diagnosis of osteosarcoma

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