Fig. 3
A 45-year-old woman with suspected lung carcinoma and newly identified bone lesion. a 18F-FDG PET/CT imaging shows uptake (SUVmax 6.4) in the bone lesion in the right tibia (yellow arrow). The maximum intensity projection image also confirms the presence of the bone lesion (red arrow). b-c The intraprocedural axial noncontrast CT image (using bone windows) shows the biopsy needle targeted within the lesion (yellow arrow). The histopathologic biopsy results (d: hematoxylin and eosin, original magnification 40×, e: hematoxylin and eosin, original magnification 100×) confirmed the bone lesion as a metastatic adenocarcinoma. Immunohistochemistry showed cancer cells: TTF-1 (+), PAX8 (−), and CK7 (+). Finally, the surgical histopathology results (f: hematoxylin and eosin, original magnification 40×, g: hematoxylin and eosin, original magnification 100×) of the bone lesion confirmed the diagnosis of bone metastases