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Table 3 Summary of sensitivity, specificity, PPV and NPV at different threshold values of the malignancy score on the independent test set

From: Independent validation of machine learning in diagnosing breast Cancer on magnetic resonance imaging within a single institution

  Performance on All Lesions in Test Set Performance on Mass Lesions in Test Set Performance on Non-mass enhancements on Test Set
Malignancy score threshold Sensitivity Specificity PPV NPV Sensitivity Specificity PPV NPV Sensitivity Specificity PPV NPV
0.00756
[Threshold value yielding 100% sensitivity on the training set]
99.5%, 419/421 9.6%, 11/114 80.3%, 419/522 84.6%, 11/13 99.3%, 291/293 10.0%, 7/70 82.2%, 291/354 77.8%, 7/9 100.0%, 128/128 9.1%, 4/44 76.2%, 128/168 100.0%, 4/4
0.05 98.1%, 413/421 35.1%, 40/114 84.8%, 413/487 83.3%, 40/48 97.6%, 286/293 38.6%, 27/70 86.9%, 286/329 79.4%, 27/34 99.2%, 127/128 29.5%, 13/44 80.4%, 127/158 92.9%, 13/14
0.1 96.7%, 407/421 43.0%, 49/114 86.2%, 407/472 77.8%, 49/63 96.6%, 283/293 47.1%, 33/70 88.4%, 283/320 76.7%, 33/43 96.9%, 124/128 36.4%, 16/44 81.6%, 124/152 80.0%, 16/20
0.2 94.3%, 397/421 54.4%, 62/114 88.4%, 397/449 72.1%, 62/86 94.9%, 278/293 55.7%, 39/70 90.0%, 278/309 72.2%, 39/54 93.0%, 119/128 52.3%, 23/44 85.0%, 119/140 71.9%, 23/32
0.3 91.9%, 387/421 64.9%, 74/114 90.6%, 387/427 68.5%, 74/108 93.2%, 273/293 65.7%, 46/70 91.9%, 273/297 69.7%, 46/66 89.1%, 114/128 63.6%, 28/44 87.7%, 114/130 66.7%, 28/42
0.4 87.9%, 370/421 73.7%, 84/114 92.5%, 370/400 62.2%, 84/135 88.7%, 260/293 74.3%, 52/70 93.5%, 260/278 61.2%, 52/85 85.9%, 110/128 72.7%, 32/44 90.2%, 110/122 64.0%, 32/50
0.5 83.6%, 352/421 82.5%, 94/114 94.6%, 352/372 57.7%, 94/163 83.3%, 244/293 84.3%, 59/70 95.7%, 244/255 54.6%, 59/108 84.4%, 108/128 79.5%, 35/44 92.3%, 108/117 63.6%, 35/55
0.6 75.8%, 319/421 89.5%, 102/114 96.4%, 319/331 50.0%, 102/204 75.1%, 220/293 88.6%, 62/70 96.5%, 220/228 45.9%, 62/135 77.3%, 99/128 90.9%, 40/44 96.1%, 99/103 58.0%, 40/69
0.7 61.3%, 258/421 91.2%, 104/114 96.3%, 258/268 39.0%, 104/267 60.1%, 176/293 91.4%, 64/70 96.7%, 176/182 35.4%, 64/181 64.1%, 82/128 90.9%, 40/44 95.3%, 82/86 46.5%, 40/86
0.8 46.1%, 194/421 96.5%, 110/114 98.0%, 194/198 32.6%, 110/337 43.0%, 126/293 97.1%, 68/70 98.4%, 126/128 28.9%, 68/235 53.1%, 68/128 95.5%, 42/44 97.1%, 68/70 41.2%, 42/102
0.9 20.0%, 84/421 99.1%, 113/114 98.8%, 84/85 25.1%, 113/450 17.7%, 52/293 98.6%, 69/70 98.1%, 52/53 22.3%, 69/310 25.0%, 32/128 100.0%, 44/44 100.0%, 32/32 31.4%, 44/140