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Table 3 Summary of sensitivity, specificity, PPV and NPV at different threshold values of the malignancy score on the independent test set

From: Independent validation of machine learning in diagnosing breast Cancer on magnetic resonance imaging within a single institution

 

Performance on All Lesions in Test Set

Performance on Mass Lesions in Test Set

Performance on Non-mass enhancements on Test Set

Malignancy score threshold

Sensitivity

Specificity

PPV

NPV

Sensitivity

Specificity

PPV

NPV

Sensitivity

Specificity

PPV

NPV

0.00756

[Threshold value yielding 100% sensitivity on the training set]

99.5%, 419/421

9.6%, 11/114

80.3%, 419/522

84.6%, 11/13

99.3%, 291/293

10.0%, 7/70

82.2%, 291/354

77.8%, 7/9

100.0%, 128/128

9.1%, 4/44

76.2%, 128/168

100.0%, 4/4

0.05

98.1%, 413/421

35.1%, 40/114

84.8%, 413/487

83.3%, 40/48

97.6%, 286/293

38.6%, 27/70

86.9%, 286/329

79.4%, 27/34

99.2%, 127/128

29.5%, 13/44

80.4%, 127/158

92.9%, 13/14

0.1

96.7%, 407/421

43.0%, 49/114

86.2%, 407/472

77.8%, 49/63

96.6%, 283/293

47.1%, 33/70

88.4%, 283/320

76.7%, 33/43

96.9%, 124/128

36.4%, 16/44

81.6%, 124/152

80.0%, 16/20

0.2

94.3%, 397/421

54.4%, 62/114

88.4%, 397/449

72.1%, 62/86

94.9%, 278/293

55.7%, 39/70

90.0%, 278/309

72.2%, 39/54

93.0%, 119/128

52.3%, 23/44

85.0%, 119/140

71.9%, 23/32

0.3

91.9%, 387/421

64.9%, 74/114

90.6%, 387/427

68.5%, 74/108

93.2%, 273/293

65.7%, 46/70

91.9%, 273/297

69.7%, 46/66

89.1%, 114/128

63.6%, 28/44

87.7%, 114/130

66.7%, 28/42

0.4

87.9%, 370/421

73.7%, 84/114

92.5%, 370/400

62.2%, 84/135

88.7%, 260/293

74.3%, 52/70

93.5%, 260/278

61.2%, 52/85

85.9%, 110/128

72.7%, 32/44

90.2%, 110/122

64.0%, 32/50

0.5

83.6%, 352/421

82.5%, 94/114

94.6%, 352/372

57.7%, 94/163

83.3%, 244/293

84.3%, 59/70

95.7%, 244/255

54.6%, 59/108

84.4%, 108/128

79.5%, 35/44

92.3%, 108/117

63.6%, 35/55

0.6

75.8%, 319/421

89.5%, 102/114

96.4%, 319/331

50.0%, 102/204

75.1%, 220/293

88.6%, 62/70

96.5%, 220/228

45.9%, 62/135

77.3%, 99/128

90.9%, 40/44

96.1%, 99/103

58.0%, 40/69

0.7

61.3%, 258/421

91.2%, 104/114

96.3%, 258/268

39.0%, 104/267

60.1%, 176/293

91.4%, 64/70

96.7%, 176/182

35.4%, 64/181

64.1%, 82/128

90.9%, 40/44

95.3%, 82/86

46.5%, 40/86

0.8

46.1%, 194/421

96.5%, 110/114

98.0%, 194/198

32.6%, 110/337

43.0%, 126/293

97.1%, 68/70

98.4%, 126/128

28.9%, 68/235

53.1%, 68/128

95.5%, 42/44

97.1%, 68/70

41.2%, 42/102

0.9

20.0%, 84/421

99.1%, 113/114

98.8%, 84/85

25.1%, 113/450

17.7%, 52/293

98.6%, 69/70

98.1%, 52/53

22.3%, 69/310

25.0%, 32/128

100.0%, 44/44

100.0%, 32/32

31.4%, 44/140