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Table 3 Summary of studies reporting clinical application of LITT in neurosurgery

From: Neurosurgical applications of MRI guided laser interstitial thermal therapy (LITT)

Reviewed studies Number of Cases Indications for LITT Outcome Comments
Schwarzmaier et al. [32] 16; 2 sets of patient (10 + 6) Recurrent glioblastoma Median survival time: 5.2 for the first set, and 11.2 in the second set Learning curve deemed responsible explaining different survival
Carpentier et al. [33] 4 Recurrent glioblastoma Mean overall survival: 10.5 months Three complications: transient dysphasia, seizure, and cerebrospinal fluid leak
Jethwa et al. [3] 20 Multiple primary brain tumors No data about survival was provided Four complications: arterial injury, refractory brain edema, pituitary injury, and misplacement of the laser probe
Banerjee et al. [2]   Recurrent grade III/IV glioblastoma Median overall survival after LITT: 20.9 months, improved compared to other treatment modalities  
Rao et al. [46] 14 Recurrent brain metastases after radiosurgery and/or whole-brain radiation Median progression-free survival: 37 weeks, and overall survival: 57%  
Carpentier et al. [44, 45] 2 studies:
2008: 4
Recurrent or resistant cerebral metastases 2008: Not reported
2011: follow-up up to 30 month, median survival was 19.8 months
Bastos et al. [60] 61 Recurrent brain metastasis and radiation necrosis Incomplete ablation and recurrent tumoral lesions were associated with a higher risk of treatment failure and were the major predicting factors for local recurrence
Systemic therapy within 3 months after LITT was a protective factor against local recurrence
Kang et al. [64] 20 Epilepsy LITT achieved a 53% rate of remission of disabling seizures  
Waseem et al. [65] 7 Epilepsy LITT achieved a 57% rate of remission of disabling seizures  
Willie et al. [26] 13 Epilepsy LITT achieved a 54% rate of remission of disabling seizures