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Table 3 Summary of studies reporting clinical application of LITT in neurosurgery

From: Neurosurgical applications of MRI guided laser interstitial thermal therapy (LITT)

Reviewed studies

Number of Cases

Indications for LITT



Schwarzmaier et al. [32]

16; 2 sets of patient (10 + 6)

Recurrent glioblastoma

Median survival time: 5.2 for the first set, and 11.2 in the second set

Learning curve deemed responsible explaining different survival

Carpentier et al. [33]


Recurrent glioblastoma

Mean overall survival: 10.5 months

Three complications: transient dysphasia, seizure, and cerebrospinal fluid leak

Jethwa et al. [3]


Multiple primary brain tumors

No data about survival was provided

Four complications: arterial injury, refractory brain edema, pituitary injury, and misplacement of the laser probe

Banerjee et al. [2]


Recurrent grade III/IV glioblastoma

Median overall survival after LITT: 20.9 months, improved compared to other treatment modalities


Rao et al. [46]


Recurrent brain metastases after radiosurgery and/or whole-brain radiation

Median progression-free survival: 37 weeks, and overall survival: 57%


Carpentier et al. [44, 45]

2 studies:

2008: 4


Recurrent or resistant cerebral metastases

2008: Not reported

2011: follow-up up to 30 month, median survival was 19.8 months


Bastos et al. [60]


Recurrent brain metastasis and radiation necrosis

Incomplete ablation and recurrent tumoral lesions were associated with a higher risk of treatment failure and were the major predicting factors for local recurrence

Systemic therapy within 3 months after LITT was a protective factor against local recurrence


Kang et al. [64]



LITT achieved a 53% rate of remission of disabling seizures


Waseem et al. [65]



LITT achieved a 57% rate of remission of disabling seizures


Willie et al. [26]



LITT achieved a 54% rate of remission of disabling seizures