Table 1 MRI of laser-ablated lesion: Immediate and early stage (0 to 3 months post procedures)
From: Neurosurgical applications of MRI guided laser interstitial thermal therapy (LITT)
Structural anatomy | Histology | MRI features | ||
|---|---|---|---|---|
T1WI | T1WI + C | T2WI | ||
Central zone | Coagulative necrosis (damage of nuclear membrane and mitochondria, engorged blood vessels, RBCs with cell membrane defects and no Hemoglobin) | Hyper | None | Hypo |
Peripheral zone | Necrotizing edema (intracellular edema, ↑granulocyte, lymphocyte, and macrophages) | Hypo | None | Hyper |
Outer rim bordering the peripheral zone | Damaged blood vessels and granulation tissue | Hypo/Hyper | Enhanced | Hypo |
Perifocal edema (outside the peripheral zone) | Vasogenic edema with viable cells | Hypo | None | Hyper |