Fig. 5

Examples of using the radiomics signature to evaluate the MGMT promoter methylation status noninvasively. A 37/M was histopathologically diagnosed with anaplastic astrocytoma with a methylated MGMT promoter (a), and a 44/M was histopathologically diagnosed with anaplastic astrocytoma with an unmethylated MGMT promoter (b). Determination of the MGMT promoter methylation status is difficult based on clinical and visually assessed imaging characteristics, but the radiomics signature demonstrated values of 0.84 (a) and 0.27 (b) in these two patients and successfully predicted their MGMT status (the cutoff value of the radiomics signature was 0.50)