Imaging and clinical features of Castleman Disease

Cancer Imaging

Table 3 Summary of the Main Computed Tomography Findings in Castleman disease (n = 69)

CT Findings	HVV (n = 57)	PCV (n = 12)	P
Clinical type			0.000
Unicentric	56	4
Multicentric	1	8
Margin			0.540
Well Circumscribed	51	12
Infiltrate into the Surrounding	6	0
Longest diameter	5.4 ± 2.4 cm (rang: 1.5 ~ 14.0 cm)	2.6 ± 1.7 cm (rang: 1.0 ~ 10.9 cm)	0.000
Homogeneity			0.450
Homogeneous	50	12
Heterogeneous	7	0
Pattern of enhancement			0.008
Homogeneous	31	12
Heterogeneous	26	0
Degree of enhancement			1
Hyper--	56	12
Iso-	0	0
Hypo-	1	0
Calcifications	18^a	0	0.057
Punctate	13	0
Branched	5^a	0
Coarse	4^a	0
Hypertrophied vessels	38	0	0.000
Feeding artery	26^b	0
Draining vein	25^b	0
Splenomegaly (n = 8)^c			0.002
Unicentric	1	1
Multicentric	0	6

UCD unicentric Castleman disease, MCD multicentric Castleman disease, HVV Hyaline vascular variant; PCV Plasma cell variant
^aIn four patients, the CD lesion presented multiple calcified areas with different patterns
^b13 patients had both the hypertrophied feeding arteries and draining veins
^c33 patients underwent abdominal scanning, including 24 UCD and 9 MCD

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