Fig. 2

The lung cancers with mixed growth pattern during two round of follow up scan. a-c A nodule re-classified from indolent to aggressive. a Baseline scan (T0). Axial CT images show an irregular nodule in right upper lobe. b The first follow up (T1), with the interval days of 406 days and VDT 5713 days. c The second follow up (T2), with the interval days of 355 days and VDT 86 days. d-f A nodule re-classified from aggressive to indolent cancer. d Baseline scan (T0). Axial CT images show an amorphous nodule in left upper lobe. e The first follow up (T1), with the interval days of 430 days and VDT 114 days. f The second follow up (T2), with the interval days of 300 days and VDT 848 days