Non-mono-exponential diffusion models for assessing early response of liver metastases to chemotherapy in colorectal Cancer

Table 2 Comparison of non-mono-exponential diffusion-related parameters before and after chemotherapy between responders and non-responders

	Parameters	Responders (n = 17)	Non-responders (n = 16)	P-value
Pre-treatment	ADC_k (10^− 3 mm²/s)	1.41 ± 0.28	1.40 ± 0.47	0.444
	K	0.77 ± 0.15	0.90 ± 0.15	0.015
	DDC (10⁻³ mm²/s)	1.15 ± 0.27	1.12 ± 0.46	0.382
	α	0.80 ± 0.05	0.78 ± 0.13	0.901
	D_s (10⁻³ mm2/s)	1.34 ± 0.37	1.42 ± 0.54	0.817
	σ	0.81 ± 0.18	1.03 ± 0.28	0.041
Post-treatment	ADC_k (10⁻³ mm²/s)	1.54 ± 0.34	1.72 ± 0.85	0.657
	K	0.76 ± 0.11	0.75 ± 0.20	0.929
	DDC (10⁻³ mm²/s)	1.24 ± 0.26	1.46 ± 0.69	0.817
	α	0.78 ± 0.09	0.77 ± 0.09	0.657
	D_s (10⁻³ mm2/s)	1.56 ± 0.37	1.73 ± 0.70	0.845
	σ	0.73 ± 0.19	0.81 ± 0.29	0.363
Variation rate	ΔADC_k (%)	12.61 ± 32.15	23.61 ± 43.74	0.510
	ΔK (%)	2.99 ± 26.25	−16.19 ± 18.23	0.021
	ΔDDC (%)	13.00 ± 34.94	34.18 ± 48.35	0.276
	Δα(%)	−2.41 ± 13.65	0.20 ± 11.96	0.986
	ΔD_s (%)	22.31 ± 33.41	29.00 ± 51.01	0.817
	Δσ(%)	−8.42 ± 20.20	−20.76 ± 18.49	0.034

ADC_k apparent diffusion coefficient from the kurtosis model, DDC distributed diffusion coefficients

ISSN: 1470-7330