Non-mono-exponential diffusion models for assessing early response of liver metastases to chemotherapy in colorectal Cancer

Table 1 Intra- and Inter-observer agreement (measured as the ICC) for the diffusion-related parameters measured before and after chemotherapy

	Parameters	Intra-observer ICC(95%CI)	P-value	Inter-observer ICC(95%CI)	P-value
Pre-treatment	ADC _k	0.914 (0.834~0.9456)	0.783	0.804 (0.639~0.898)	0.914
	K	0.929 (0.861~0.964)	0.893	0.717 (0.500~0.850)	0.453
	DDC	0.948 (0.898~0.974)	0.913	0.706 (0.485~0.842)	0.207
	α	0.918 (0.841~0.959)	0.788	0.877 (0.767~0.937)	0.453
	D _s	0.937 (0.877~0.968)	0.964	0.887 (0.784~0.942)	0.903
	σ	0.924 (0.852~0.961)	0.863	0.816 (0.659~0.904)	0.631
Post-treatment	ADC _k	0.955 (0.910~0.977)	0.842	0.811 (0.650~0.902)	0.715
	K	0.932 (0.867~0.965)	0.734	0.874 (0.762~0.936)	0.724
	DDC	0.937 (0.877~0.968)	0.744	0.798 (0.630~0.895)	0.256
	α	0.853 (0.724~0.924)	0.547	0.824 (0.637~0.914)	0.314
	D _s	0.914 (0.834~0.957)	0.658	0.804 (0.639~0.898)	0.893
	σ	0.948 (0.899~0.974)	0.852	0.708 (0.486~0.844)	0.842

ICC inter-class correlation coefficient, ADC_k apparent diffusion coefficient from the kurtosis model, DDC distributed diffusion coefficients

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