Table 2 Forty-two histogram features in the EGFR(+) group and the EGFR(−) group are presented as median (25, 75%), respectively, and a p value was derived on the basis of a statistically significant difference between each feature and EGFR mutation status
Features | EGFR(+) | EGFR(−) | P value |
|---|---|---|---|
Min Intensity | −58.00 (− 212.00, 2.00) | −16.00 (−67.00, 26.75) | 0.106 |
Max Intensity | 1073.00 (894.50, 1272.00) | 772.50 (449.50, 1077.50) | 0.002* |
Median Intensity | 369.35 (106.54, 565.63) | 108.92 (70.63, 208.23) | 0.002* |
Mean Value | 373.53 (140.51, 551.41) | 131.17 (84.15, 227.16) | 0.002* |
Std Deviation | 145.44 (118.97, 245.85) | 88.09 (57.75, 155.43) | 0.001* |
Variance | 21,151.80 (14,163.10, 60,442.60) | 7766.17 (3340.58, 24,158.58) | 0.001* |
Volume Count | 6047.00 (2462.00, 14,622.50) | 4164.00 (1623.75, 9188.50) | 0.245 |
Voxel Value Sum | 1,840,000.00 (492,161.00, 7,150,000.00) | 745,705.00 (199,724.75, 2,115,000.00) | 0.013* |
Range | 1183.00 (888.00, 1401.00) | 756.50 (478.25, 1113.25) | 0.001* |
RMS | 389.84 (196.88, 594.39) | 183.50 (100.74, 294.90) | 0.001* |
Mean Deviation | −118.53 (− 296.44, 114.50) | 123.84 (27.84, 170.85) | 0.002* |
Relative Deviation | − 1058.43 (− 5577.42, 2235.28) | 2337.26 (− 404.51, 8608.66) | 0.009* |
Skewness | 0.40 (−0.19, 1.17) | 1.22 (0.32, 2.32) | 0.011* |
Kurtosis | 0.62 (−0.39, 2.18) | 2.16 (−0.14, 7.21) | 0.165 |
Uniformity | 0.52 (0.24, 0.66) | 0.32 (0.19, 0.63) | 0.225 |
Histogram Energy | 0.01 (0.01, 0.01) | 0.01 (0.01, 0.02) | 0.213 |
Histogram Entropy | 7.01 (6.72, 7.32) | 6.76 (6.22, 7.24) | 0.137 |
Frequency Size | 6046.00 (2461.00, 14,621.50) | 4163.00 (1622.75, 9187.50) | 0.245 |
Percentile 5 | 111.25 (30.33, 195.40) | 34.94 (6.94, 104.10) | 0.047* |
Percentile 10 | 187.31 (41.50, 283.71) | 40.98 (21.68, 125.22) | 0.021* |
Percentile 15 | 220.21 (49.21, 337.86) | 45.55 (31.17, 139.97) | 0.012* |
Percentile 20 | 239.05 (56.38, 384.60) | 49.92 (37.47, 151.24) | 0.007* |
Percentile 25 | 267.93 (62.89, 433.14) | 53.39 (41.39, 160.71) | 0.005* |
Percentile 30 | 298.39 (68.42, 468.12) | 56.89 (47.82, 170.64) | 0.004* |
Percentile 35 | 316.22 (75.99, 493.25) | 60.53 (52.20, 179.06) | 0.001* |
Percentile 40 | 333.97 (82.54, 517.86) | 70.52 (62.42, 187.81) | 0.002* |
Percentile 45 | 349.95 (93.92, 541.96) | 91.71 (66.74, 198.01) | 0.002* |
Percentile 50 | 368.77 (107.44, 564.66) | 109.48 (70.20, 208.48) | 0.002* |
Percentile 55 | 382.74 (123.39, 583.52) | 119.17 (74.45, 221.36) | 0.002* |
Percentile 60 | 395.80 (140.10, 608.67) | 130.12 (79.11, 240.573) | 0.001* |
Percentile 65 | 409.11 (161.26, 638.45) | 140.19 (84.52, 265.378) | 0.001* |
Percentile 70 | 430.82 (183.03, 673.18) | 153.89 (93.23, 296.70) | 0.001* |
Percentile 75 | 452.70 (207.13, 724.34) | 168.34 (101.78, 333.79) | 0.001* |
Percentile 80 | 469.42 (235.15, 777.98) | 186.77 (117.55, 376.72) | 0.001* |
Percentile 85 | 504.88 (270.93, 833.95) | 211.65 (132.75, 433.35) | 0.001* |
Percentile 90 | 558.05 (320.99, 880.90) | 272.33 (150.66, 498.35) | 0.001* |
Percentile 95 | 638.65 (403.52, 970.84) | 331.95 (184.23, 534.20) | 0.001* |
Quantile 0.025 | 83.39 (7.50, 139.66) | 27.60 (0.02, 83.78) | 0.272 |
Quantile 0.25 | 267.93 (62.89, 433.14) | 53.39 (41.39, 160.71) | 0.005* |
Quantile 0.5 | 368.77 (107.44, 564.66) | 109.48 (70.20, 208.48) | 0.002* |
Quantile 0.75 | 452.70 (207.13, 724.34) | 168.34 (101.78, 333.79) | 0.001* |
Quantile 0.975 | 704.95 (488.12, 1030.14) | 395.74 (229.79, 606.97) | 0.001* |