Intra-individual comparison of 68Ga-PSMA-11 and 18F-DCFPyL normal-organ biodistribution

Cancer Imaging

Table 2 Comparison of ⁶⁸Ga-PSMA-11 and ¹⁸F-DCFPyL quantitative uptake in each of the target organs

Target Organ	⁶⁸Ga-PSMA-11 SUV_peak		¹⁸F-DCFPyL SUV_peak		Paired test P value	Linear Regression			Bland-Altman
Target Organ	Mean (SD) or Median (IQR)	CoV (%)	Mean (SD) or Median (IQR)	CoV (%)	Paired test P value	Slope	R²	P value	Mean Bias	SD
Lacrimal Glands	6.4 (1.71)^a	26.7	6.0 (1.95)^a	32.3	0.140^b	0.767	0.456	< 0.001	−0.39	1.489
Parotid Glands	16.9 (4.16)^a	24.6	14.8 (4.20)^a	28.4	< 0.001 ^b	0.845	0.699	< 0.001	−2.08	2.394
Submandibular Glands	17.9 (4.53)^a	25.4	14.6 (4.78)^a	32.7	< 0.001 ^b	0.910	0.743	< 0.001	−3.21	2.458
Liver	6.7 (1.48)^a	21.9	7.5 (1.69)^a	22.5	0.001 ^b	0.767	0.449	< 0.001	0.79	1.305
Spleen	9.4 (3.84)^c	36.8	4.9 (1.53)^c	45.3	< 0.001 ^d	0.616	0.820	< 0.001	−4.49	1.781
Duodenum	14.0 (5.37)^c	30.9	9.6 (5.18)^c	29.8	< 0.001 ^d	0.291	0.203	0.008	−4.87	4.138
Kidneys	59.6 (14.77)^a	24.8	40.0 (12.43)^a	31.1	< 0.001 ^b	0.645	0.587	< 0.001	−19.60	9.561
Bladder	43.1 (41.02)^c	91.4	57.3 (28.94)^c	78.9	0.033^d	−0.128	0.011	0.549	20.36	78.100
Aorta	1.3 (0.29)^a	21.9	1.4 (0.21)^a	15.5	0.033^b	0.404	0.286	0.001	0.10	0.250
Muscle	0.5 (0.13)^a	28.3	0.3 (0.09)^a	26.7	< 0.001 ^b	0.251	0.140	0.029	−0.15	0.128

For data normally distributed: ^a mean (SD); ^b Paired t test. For data not normally distributed: ^c Median (IQR); ^d Wilcoxon signed-rank test.
P values in bold reflect statistical significance
SD Standard Deviation, IQR Interquartile Range, CoV Coefficient of Variation

ISSN: 1470-7330