Probabilistic independent component analysis of dynamic susceptibility contrast perfusion MRI in metastatic brain tumors

Table 2 ROC curve analyses representing differentiation of Breast vs. Other, NSCLC vs. Other, Breast vs. NSCLC and pooled Breast & NSCLC groups vs. Other

Parameter	AUC	Cut-off value	Specificity	Sensitivity
Breast vs. Other
Tumor Volume [μl]	0.62	866	45.3	81.5
ADC [μm2/ms]	0.533	1.423	25.3	91.2
rCBV [a.u.]	0.547	2.923	73.5	43.1
Arterial [%]	0.692	21.809	62.8	75
Overlap [%]	0.56	54.138	65.2	61.6
Venous [%]	0.698	68.688	90	44.1
NSCLC vs. Other
Tumor Volume [μl]	0.627	266	68.7	65.3
ADC [μm2/ms]	0.513	0.972	39.2	72.9
rCBV [a.u.]	0.51	0.991	87.8	23.1
Arterial [%]	0.658	29.26	72.9	55.4
Overlap [%]	0.562	18.506	80.3	38.8
Venous [%]	0.518	10.514	32.6	80
Breast vs. NSCLC
Tumor Volume [μl]	0.471	1069	25.2	83.3
ADC [μm2/ms]	0.562	0.991	66.1	47.2
rCBV [a.u.]	0.554	1.174	28.1	86.2
Arterial [%]	0.516	9.645	25.7	87.5
Overlap [%]	0.616	56.675	73.2	48.3
Venous [%]	0.687	46.666	78.4	58.8
Breast & NSCLC vs. Other
Tumor Volume [μl]	0.625	556	54	68.8
ADC [μm2/ms]	0.5	1.417	26.1	84.8
rCBV [a.u.]	0.508	2.886	73.5	47.4
Arterial [%]	0.666	20.202	62.8	76.3
Overlap [%]	0.523	18.51	80.3	44.6
Venous [%]	0.583	72.72	92.9	33.4

Tumor volume, ADC, rCBV, ICA-derived arterial, overlap, and venous components were analyzed. For each parameter, area under curve (AUC) representing the accuracy of the measurement, cut-off value, specificity and sensitivity (expressed in %) are reported
BOLD rows in the table represent total characteristics for the entire patient cohort examined in the current study

ISSN: 1470-7330