Fig. 2
Multiparametric MRI images in patients with secondary brain metastasis from a) breast, b) NSCLC and c) clear cell kidney carcinoma. Pre- and post-contrast T1-weigthed, T2-weighted FLAIR, T1 subtraction (ΔT1 map), ADC, normalized rCBV and arterio-venous overlap (AVOL) maps for each representative patient. Inhomogeneous tumor lesions were defined and overlaid on ΔT1 map excluding central necrotic areas (red rectangles). T2-weighted FLAIR shows peri-enhancing edema on both breast and clear cell kidney carcinoma cases. ADC maps shows reduced diffusion values within solid component of the tumor (contrast enhancement) and increased diffusion in edematous component. This former region is characterized by hypoperfused blood volume (low rCBV) while solid component is mostly hyperperfused. AVOL maps are heterogeneous for both arterial and venous components while in clear cell kidney carcinoma case, tumor region is predominated by overlap map