Prediction of high nodal burden with ultrasound and magnetic resonance imaging in clinically node-negative breast cancer patients

Table 4 Univariate and multivariate analyses for prediction of high nodal burden

Characteristics	Univariate Analysis		Multivariate Analysis
Characteristics	Odds Ratio	P value	Odds Ratio	P value
Ultrasound
T stage
T1	1.00		1.00
≥ T2	6.13 (2.32, 16.22)	<.001	5.65 (1.71, 18.69)	.005
Number of suspicious ALNs
0–1	1.00		1.00
2	19.58 (5.34, 71.83)	<.001	6.52 (1.36, 31.28)	.019
≥ 3	52.22 (10.78, 252.97)	<.001	21.08 (2.57, 172.86)	.005
Cortical morphologic changes^a
Grade 1	1.00		1.00
Grade 2	5.63 (1.46, 21.71)	.012	2.70 (0.60, 12.10)	.193
Grade 3	51.20 (11.76, 222.98)	<.001	9.85 (1.37, 71.00)	.023
SD
< 5 mm	1.00		1.00
5–10 mm	1.84 (0.65, 5.19)	.251	1.00 (0.28, 3.50)	.996
> 10 mm	15.10 (2.91, 78.44)	.001	1.00 (0.05, 18.36)	.998
MRI
T stage
T1	1.00		1.00
≥ T2	6.13 (2.32, 16.22)	<.001	5.17 (1.46, 18.34)	.011
Number of suspicious ALNs
0–1	1.00		1.00
2	35.16 (8.94, 138.31)	<.001	69.00 (5.28, 901.25)	.001
≥ 3	47.36 (10.87, 206.38)	<.001	93.55 (7.89, 1108.67)	< .001
Cortical morphologic changes^a
Grade 1	1.00		1.00
Grade 2	3.10 (0.75, 12.71)	.117	0.57 (0.05, 5.97)	.638
Grade 3	13.87 (3.44, 55.91)	<.001	0.44 (0.03, 6.96)	.557
SD
< 5 mm	1.00		1.00
5–10 mm	1.61 (0.48, 5.40)	.437	0.35 (0.04, 2.94)	.336
> 10 mm	6.71 (1.51, 29.95)	.013	0.57 (0.04, 8.71)	.687
LD
< 10 mm	1.00		1.00
10–15 mm	2.24 (0.63, 7.89)	.210	1.06 (0.17, 6.74)	.948
> 15 mm	3.84 (1.03, 14.27)	.045	1.39 (0.16, 12.28)	.765

SD short diameter, LD long diameter
^aCortical morphologic changes were classified on a scale of grade 1–3: grade 1, cortical thickness of the most suspicious ALN < 2 mm; grade 2, 2–5 mm; grade 3, ≥ 5 mm or the presence of fatty hilum loss

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