Table 3 Comparison of size, 68Ga-PSMA-HBED-CC uptake (SUVmax) and radiodensity (HUmean) between pulmonary metastases (all, PSMA-positive and PSMA-negative) and opacities. PSMA-positive lung metastases demonstrated the highest tracer uptake, significantly higher than pulmonary opacities, whereas PSMA-negative metastases demonstrated the lowest tracer uptake, significantly lower than pulmonary opacities (both p<0.001). All pulmonary metastases taken together, the mean SUVmax of pulmonary metastases and opacities did not significantly differ (p>0.05). SUV max Maximum standardized uptake value, HU mean Mean Hounsfield units.
All pulmonary metastases | PSMA-positive pulmonary metastases | PSMA-negative pulmonary metastases | Pulmonary opacities | p-valuea | Aorta | p-valueb | |
|---|---|---|---|---|---|---|---|
Diameter in mm | 10.96±6.29 (5.2 – 35.8) | 11.82±6.98 (5.2 – 35.8) | 8.71±3.05 (6.0 – 21.7) | >0.05 | |||
SUVmax 2D ROI | 3.52±2.78 (0.35 – 13.85) | 2.24±0.73 (1.27 – 3.71) | >0.05 | 1.54±0.34 (0.91 – 2.32) | = 0.001 | ||
4.48±2.68 (1.54 – 13.85) | < 0.001 | ||||||
0.99±0.46 (0.35 – 2.13) | < 0.001 | ||||||
SUVmax 3D ROI | 3.71±2.96 (0.35 – 15.08) | 2.41±0.81 (1.35 – 4.10) | >0.05 | 1.57±0.34 (0.88 – 2.20) | < 0.001 | ||
4.74±2.86 (1.75 – 15.08) | < 0.001 | ||||||
1.01±0.44 (0.35 – 1.96) | < 0.001 | ||||||
HUmean, non-CE CT | -211.92±164.02 (-710.96 – 50.44) | -199.30+-175.84 (-710.96 – 50.44) | -237.16+-138.89 (-632.3 – -67.5) | ||||
HUmean, CE CT | -129.78±133.70 (-664.77 – 25.38) | -130.37+-145.70 (-664.77 – 25.38) | -127.44+-74.62 (-220.57 – -2.44) |