Fig. 5
From: Crizotinib Associated Renal Cysts [CARCs]: incidence and patterns of evolution
Resolution of CARCs without ceasing crizotinib in patient 11: Baseline scan demonstrated an 8 mm cyst in the right kidney (a). Enlarging right renal cyst with no complex features and the new left renal cyst with mixed solid and cystic areas and poorly defined margins (b). A new right upper pole cyst with septations is not shown. CT guided aspiration/ biopsy of the left renal lesion revealed xanthogranulomatous inflammation (Haematoxylin and eosin, original magnification x200) (c). All three cysts spontaneously resolved with ongoing Crizotinib therapy (d). Graph: Maximum renal cyst diameter (mm) versus days on crizotinib, demonstrating evolution of the three cysts in this patient (e)