CT texture analysis: a potential tool for prediction of survival in patients with metastatic clear cell carcinoma treated with sunitinib

Table 2 Imaging parameters as predictors of OS

Variable	P-value	Hazard ratio	95% CI
Mean positive pixel intensity prior to treatment	0.34	1.01	0.98 – 1.05
Mean positive pixel intensity following treatment	0.77	1.00	0.99 – 1.02
SD prior to treatment	0.24	0.98	0.96 – 1.01
SD following treatment	0.46	0.99	0.98 – 1.01
Entropy prior to treatment	0.27	1.74	0.65 – 4.68
Entropy following treatment	0.02	2.68	1.14 – 6.29
nSD prior to treatment	0.01	0.01	0.00 – 0.29
nSD following treatment	0.01	0.02	0.001 – 0.39
Kurtosis prior to treatment	0.26	1.24	0.85 – 1.82
Kurtosis following treatment	0.78	1.03	0.81 – 1.32
Skewness prior to treatment	0.15	2.02	0.77 – 5.30
Skewness following treatment	0.30	1.47	0.70 – 3.09
Percent change in size	0.02	0.97	0.94 – 0.99
Mean pixel intensity Change	0.37	0.99	0.98 – 1.01
SD Change	0.80	1.14	0.42 – 3.09
Entropy Change	0.04	87.77	1.26 – 6115.69
nSD Change	0.39	0.18	0.004 – 8.56
Kurtosis Change	0.46	0.66	0.21 – 2.02
Skewness Change	0.98	0.99	0.60 – 1.65

Entries in bold were significant
Abbreviations: SD standard deviation, nSD size normalized standard deviation OS overall survival

ISSN: 1470-7330