The role of diffusion and perfusion weighted imaging in the differential diagnosis of cerebral tumors: a review and future perspectives

Svolos, Patricia; Kousi, Evanthia; Kapsalaki, Eftychia; Theodorou, Kyriaki; Fezoulidis, Ioannis; Kappas, Constantin; Tsougos, Ioannis

doi:10.1186/1470-7330-14-20

Table 1 Published studies regarding glioma grading and the differentiation of metastatic tumors (MT) from high-grade gliomas (HGG)

From: The role of diffusion and perfusion weighted imaging in the differential diagnosis of cerebral tumors: a review and future perspectives

	Authors	No. patients	Area of measurement	Technique	Diagnostic outcome
Glioma Grading	Kono et al. [52]	17	Intra/Peritumoral	DWI	Intratumoral ADC higher in LGG than GBM
	Kremer et al. [7]	36	Intratumoral	DSCI	rCBV lower in LGG than HGG
	Beppu et al. [57]	31	Intratumoral	DTI	FA lower in LGG than HGG
	Preul et al. [64]	33	Intratumoral	DSCI	rCBV lower in LGG than HGG
	Law et al. [65]	63	Intratumoral	DSCI	rCBV lower in LGG than GBM
	Inoue et al. [55]	41	Intratumoral	DTI	MD higher in LGG than HGG
	Inoue et al. [55]	41	Intratumoral	DTI	FA lower in LGG than HGG
	Fan et al. [45]	22	Intra/Peritumoral	DWI	Intratumoral ADC higher in LGG than AA
	Hakyemez et al. [101]	33	Intratumoral	DSCI	rCBV lower in LGG than GBM
	Stadlbauer et al. [53]	20	Intratumoral	DTI	FA higher in LGG than HGG
	Zonari et al. [48]	105	Intratumoral	DSCI	rCBV lower in LGG than GBM
	Lee et al. [56]	27	Intratumoral	DTI	MD higher in LGG than HGG
	Di Costanzo et al. [63]	36	Intra/Peritumoral	DSCI	Intra/Peritumoral rCBV lower in LGG than HGG
	Rizzo et al. [49]	35	Intratumoral	DSCI	rCBV lower in LGG than HGG
	Senturk et al. [62]	26	Intratumoral	DSCI	rCBV lower in LGG than HGG
	Chen et al. [59]	31	Intra/Peritumoral	DTI	Peritumoral FA higher in LGG than HGG
	Liu et al. [3]	52	Intratumoral	DTI	FA lower in LGG than HGG
	Svolos et al. [47]	73	Intra/Peritumoral	DWI	Intratumoral ADC higher in LGG than HGG
					Peritumoral ADC lower in LGG than HGG
				DSCI	Intra/Peritumoral rCBV lower in LGG than HGG
MT vs. HGG	Chiang et al. [92]	12	Intra/Peritumoral	DSCI	Peritumoral rCBV lower in MT than HGG
	Lu et al. [9]	20	Intra/Peritumoral	DTI	Peritumoral MD higher in MT than GBM
	Server et al. [8]	82	Intra/Peritumoral	DWI	Intratumoral ADC lower in MT than GBM
	Pavlisa et al. [97]	40	Intra/Peritumoral	DWI	Peritumoral ADC higher in MT than GBM
	Wang et al. [98]	63	Intra/Peritumoral	DTI	Intra/Peritumoral FA lower in MT than GBM
	Senturk et al. [62]	18	Intra/Peritumoral	DSCI	Peritumoral rCBV lower in MT than GBM
	Hakyemez et al. [1]	48	Intra/Peritumoral	DSCI	Peritumoral rCBV lower in MT than GBM
	Lee et al. [99]	73	Intra/Peritumoral	DWI	Peritumoral ADC higher in MT than GBM
	Wang et al. [10]	51	Intra/Peritumoral	DTI	Intra/Peritumoral FA lower in MT than GBM
	Wang et al. [10]	51	Intra/Peritumoral	DSCI	Peritumoral rCBV lower in MT than GBM
	Server et al. [94]	61	Intra/Peritumoral	DSCI	Peritumoral rCBV lower in MT than GBM
	Tsougos et al. [11]	49	Intra/Peritumoral	DSCI	Peritumoral rCBV lower in MT than GBM
	Lehmann et al. [93]	24	Peritumoral	DSCI	rCBV lower in MT than GBM.
	Svolos et al. [47]	71	Intra/Peritumoral	DTI	Peritumoral FA lower in MT than HGG
	Svolos et al. [47]	71	Intra/Peritumoral	DSCI	Peritumoral rCBV lower in MT than HGG

The number of patients, the investigated tumor areas, the most useful imaging techniques and the diagnostic outcome for each case are summarized in the Table.

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