Table 3 Performance of air-containing space and other CT features in differentiating GGNs
CT features | Non-neoplastic GGNs (n = 465) | Neoplastic GGNs (n = 1350) | P-value | ROC analysis | |||
|---|---|---|---|---|---|---|---|
AUC (95% CI) | Sensitivity (%) | Specificity (%) | P-value | ||||
Air bronchogram | 80 (17.2) | 407 (30.1) | < 0.001 | 0.565 (0.536–0.594) | 30.1 | 82.8 | < 0.001 |
BLL | 12 (2.6) | 175 (13.0) | < 0.001 | 0.607 (0.570–0.644) | 27.8 | 93.6 | < 0.001 |
Regular shape | 291 (62.6) | 1117 (82.7) | < 0.001 | 0.601 (0.570–0.632) | 82.7 | 37.4 | < 0.001 |
Well-defined boundary | 233 (50.1) | 1114 (82.5) | < 0.001 | 0.661 (0.631–0.692) | 82.7 | 49.6 | < 0.001 |
Spiculation sign | 35 (7.5) | 115 (8.5) | 0.287 | 0.512 (0.465–0.560) | 23.3 | 74.2 | 0.613 |
Lobulation sign | 87 (18.7) | 451 (33.4) | < 0.001 | 0.567 (0.539–0.595) | 16.2 | 70.4 | 0.014 |
Pleural indentation | 51 (11.0) | 214 (15.9) | 0.005 | 0.537 (0.501–0.574) | 19.2 | 73.3 | 0.052 |