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Table 2 Univariate and multivariate proportional hazards regression analysis in predicting overall survival (OS) in late stage (stage III & IV) Hepatocellular Carcinoma (HCC) patients undergoing dual-tracer PET-CT for staging. Shaded boxes denote statistically significant variables

From: Prognostic PET [11C]-acetate uptake is associated with hypoxia gene expression in patients with late-stage hepatocellular carcinoma – a bench to bed study

 

Univariate analysis

Multivariate analysis

HR (95% CI)

P

HR (95% CI)

P

Age > 60 years

1.00 (1–1)

0.08

2.70 (1.30–5.70)

0.007

Gender (male)

0.35 (0.15–0.82)

0.016

0.5 (0.20–1.26)

0.143

Solitary

0.95 (0.51–1.80)

0.88

0.4 (0.19–0.91)

0.028

Tumor Size > 4 cm

1.70 (0.62–14.90)

0.3

0.67 (0.17–2.6)

0.57

PV thrombosis

1.60 (0.77–3.5)

0.20

2.8 (1.05–7.57)

0.041

AFP > 200 ng/ml

1.90 (1–30.5.00)

0.051

0.86 (0.38–1.96)

0.721

With [11C]-acetate

0.28 (0.14–0.57)

0.00048

0.15 (0.06–0.42)

0.00043

With [18F]-FDG

2.20 (1.00–4.80)

0.051

1.94 (0.63–5.96)

0.248

Without aetiology

0.69 (0.36–1.30)

0.26

0.58 (0.30–1.20)

0.137