Fig. 6

Metabolic aberration Analysis Using PET Normative Database. This figure presents a method for evaluating patient PET scans against a PET normative database. The first panel shows the averaged data from a healthy cohort forming the normative PET database, therefore providing a reference for typical tracer distribution. The second panel displays a lung cancer patient’s PET image, where abnormalities are indicated with arrows. The patient’s PET image is diffeomorphically aligned with the Normative database, and the deviations from the normalcy are calculated as z-maps. In the third panel, the patient’s PET data is overlaid with a z-map, highlighting deviations from the normative model. The fourth panel further overlays the z-map onto the patient’s CT image, offering anatomical context to the functional PET data. The colour scale on the far right indicates standard deviations from the normative mean, with warmer colours denoting higher deviations