Radiomics signature for dynamic changes of tumor-infiltrating CD8+ T cells and macrophages in cervical cancer during chemoradiotherapy

Table 2 Risk factors for treatment response in cervical cancer

Variable	Univariate Logistic Regression			Multivariate Logistic Regression
Variable	OR (95% CI)	p	AUC	OR (95% CI)	p
Immune score (per 0.1 increase)	12.267 (1.493-100.770)	0.020 *	0.842	32.448 (1.430-735.592)	0.029 *
Age (years) (<60 vs. ≥60)	2.963 (0.596-14.730)	0.184	0.620	NA	NA
FIGO stage (I~II vs. III~IV)	0.185 (0.038-0.893)	0.036 *	0.699	NA	NA
Tumor size (cm) (<4 vs. ≥4)	0.094 (0.010-0.891)	0.039 *	0.697	NA	NA
LNs metastasis (Negative vs. Positive)	0.341 (0.076-1.522)	0.159	0.631	NA	NA
Pre-NLR (Low vs. High)	0.074 (0.008-0.704)	0.023 *	0.726	NA	NA
Pre-PNR (Low vs. High)	2.531 (0.557-11.512)	0.229	0.611	NA	NA
Pre-PLR (Low vs. High)	0.095 (0.017-0.529)	0.007 *	0.758	NA	NA
Pre-LMR (Low vs. High)	18.667 (1.879-185.406)	0.012 *	0.740	36.366 (1.050-1255.634)	0.047 *
10F-NLR (Low vs. High)	0.311 (0.068-1.430)	0.133	0.640	NA	NA
10F-PNR (Low vs. High)	0.137 (0.027-0.695)	0.016 *	0.729	NA	NA
10F-PLR (Low vs. High)	0.114 (0.018-0.716)	0.020 *	0.710	NA	NA
10F-LMR (Low vs. High)	10.833 (1.961-59.836)	0.006 *	0.767	20.348 (1.100-377.655)	0.043 *

Abbreviations: NA Not available, LNs metastasis Lymph nodes metastasis, Pre-NLR Neutrophil lymphocyte ratio before treatment, Pre-PNR Platelet neutrophil ratio before treatment, Pre-PLR Platelet lymphocyte ratio before treatment, Pre-LMR Lymphocyte monocyte ratio before treatment, 10F-NLR Neutrophil lymphocyte ratio after 10F RT, 10F-PNR Platelet neutrophil ratio after 10F RT, 10F-PLR platelet lymphocyte ratio after 10F RT, 10F-LMR Lymphocyte monocyte ratio after 10F RT
Significance: * p value < 0.05

ISSN: 1470-7330