Value of diffusion kurtosis MR imaging and conventional diffusion weighed imaging for evaluating response to first-line chemotherapy in unresectable pancreatic cancer

Table 4 ROC curve of DWI and DKI parameters in differentiating chemotherapy efficacy in patients with unresectable pancreatic cancer

Parameters	AUC	95%CI	P value	Sensitivity	Specialty	Cut off value	Youden’s index*
ADC_pre	0.52	0.295–0.740	0.8798	0.714	0.5	>0.9838	0.2143
MK_pre	0.571	0.340–0.782	0.5851	1	0.286	≤ 0.7531	0.2857
MD_pre	0.684	0.447–0.866	0.1484	0.857	0.571	≤ 1.8623	0.4286
ADC_post	0.714	0.478–0.887	0.0872	0.714	0.786	>0.9838	0.5
MK_post	0.633	0.397–0.829	0.2935	1	0.5	≤ 0.6295	0.5
MD_post	0.67	0.437–0.859	0.21	0.57	0.86	>2.3917	0.43
ADC_change	0.806	0.577–0.944	0.0017	1	0.643	>0.1369	0.6429
MK_change	0.571	0.340–0.782	0.6295	0.286	0.929	≤-0.2301	0.2143
MD_change	0.898	0.687–0.986	<0.0001	0.857	0.857	>0.1373	0.7143
SUM_change	0.912	0.788–0.988	0.002	0.857	0.857	>0.1477	0.7143

*Youden’s index = sensitivity − (1 - specificity); 95% CI, 95% confidence interval;SUM_change = ((ADC_post+MD_post)-(ADC_pre+MD_pre)) / (ADC_pre+MD_pre)

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