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Table 2 Baseline and imaging characteristics of responders and non-responders in the training set

From: Development and validation of a nomogram model based on pretreatment ultrasound and contrast-enhanced ultrasound to predict the efficacy of neoadjuvant chemotherapy in patients with borderline resectable or locally advanced pancreatic cancer

Imaging characteristics

Responders(34)

Non-responders(43)

P value

Age(year)

59.53 ± 1.60

61.16 ± 1.24

0.42

Sex (Male/Female)

17/17

26/17

0.36

CA19-9(U/mL)

512.68 ± 198.26

896.84 ± 216.89

0.05

Location

  

0.93

 Head or neck

13

16

 

 Body or tail

21

27

 

Tumor size(cm)

4.27 ± 0.22

4.83 ± 0.20

0.04

Nature

  

0.72

 Solid

28

34

 

 Cystic-solid

6

9

 

MPD dilation (> 4 mm)

12

11

0.36

Lobulated lesion shape

8

21

0.02

Celiac artery involvement

8

15

0.28

Taller-than-wide shape in the longitudinal plane

12

33

 < 0.01

Taller-than-wide shape in the cross plane

8

15

0.28

Blood flow in color doppler

10

13

0.94

Necrosis

4

12

0.08

CEUS patterns

   

 Arterial phase

  

0.50

  Iso-enhancement

20

22

 

   Hypo-enhancement

14

21

 

 Venous phase

  

0.01

  Rapid washout

33

33

 

   Slow washout

1

10

 

 TTP

  

 < 0.01

   ≤ 25 s

25

11

 

   > 25 s

9

32

 

 Peaktumor/Peaknormal

0.63 ± 0.03

0.47 ± 0.03

 < 0.01

Treatment

   

 AG

15

26

0.15

 AS

19

17

 
  1. MPD Main pancreatic duct, CEUS Contrast-enhanced ultrasound, TTP Time from injection of contrast agent to peak enhancement, Peaktumor/Peaknormal Tumor/surrounding pancreatic parenchyma ratio of enhancement, AG Nab-paclitaxel + gemcitabine, AS Nab-paclitaxel + tegafur