Dual-modal radiomics nomogram based on contrast-enhanced ultrasound to improve differential diagnostic accuracy and reduce unnecessary biopsy rate in ACR TI-RADS 4–5 thyroid nodules

Table 7 Predictive value of the dual-modal ultrasound radiomics scores in terms of NRI and IDI

Variable	Training cohort			Validation cohort			Entire cohort
Variable	Categorical NRI (95% CI)	Continuous NRI (95% CI)	IDI (95% CI)	Categorical NRI (95% CI)	Continuous NRI (95% CI)	IDI (95% CI)	Categorical NRI (95% CI)	Continuous NRI (95% CI)	IDI (95% CI)
BMUS Rad-score	0.093 (-0.026-0.212)	0.532 (0.253–0.812)	0.056 (0.020–0.092)	0.1633 (-0.057-0.384)	0.2929 (-0.151-0.737)	0.083 (0.015–0.150)	0.114 (0.008–0.2197)	0.461 (0.224–0.698)	0.064 (0.032–0.096)
P value	0.125	0.002	0.002	0.147	0.196	< 0.05	0.035	< 0.001	< 0.001
CEUS Rad-score	0.2338 (0.091–0.377)	0.6851 (0.411–0.959)	0.122 (0.064–0.180)	0.244 (-0.001-0.489)	0.983 (0.586–1.380)	0.148 (0.058–0.237)	0.237 (0.113–0.361)	0.772 (0.546–0.999)	0.130 (0.081–0.178)
P value	0.001	< 0.05	< 0.001	0.05	< 0.05	0.001	< 0.001	< 0.001	< 0.001
BMUS + CEUS Rad-score	0.247 (0.096–0.398)	0.759 (0.488–1.029)	0.152 (0.089–0.216)	0.303 (0.070–0.536)	0.788 (0.372–1.203)	0.176 (0.077–0.276)	0.263 (0.135–0.390)	0.767 (0.540–0.994)	0.159 (0.106–0.213)
P value	0.001	< 0.05	< 0.05	< 0.05	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001

Note: NRI = net reclassification improvement, IDI = index integrated discrimination improvement, CI = confidence interval = BMUS = B-mode ultrasound, CEUS = contrast-enhanced ultrasound

ISSN: 1470-7330