Table 3 Predictive performance of the ACR TI-RADS for TI-RADS 4 and 5 thyroid nodules
Variable | Value (95% CI) | ||
|---|---|---|---|
Training cohort (n = 219) | Validation cohort (n = 93) | Entire cohort (n = 312) | |
Cutoff value | 0.586 | 0.586 | 0.586 |
AUC | 0.653 (0.588–0.719) | 0.669 (0.567–0.772) | 0.658 (0.603–0.713) |
Sensitivity, % | 88.2 (83.0-93.5) | 89.4 (81.8–97.0) | 88.6 (84.5–92.7) |
Specificity, % | 42.4 (30.3–54.5) | 44.4 (25.9–63.0) | 43.0 (33.3–52.7) |
PPV, % | 78.0 (71.9–84.2) | 79.7 (70.6–88.9) | 78.5 (73.4–83.7) |
NPV, % | 60.9 (46.8–75.0) | 63.2 (41.5–84.8) | 61.5 (49.7–73.4) |
PLR | 2.771 (1.925–3.988) | 3.116 (1.766–5.496) | 2.868 (2.111–3.896) |
NLR | 0.501 (0.347–0.725) | 0.462 (0.254–0.842) | 0.490 (0.358–0.671) |
Accuracy, % | 74.4 (68.1–80.1) | 76.3 (66.4–84.5) | 75.0 (69.8–79.7) |