Table 1 Patient Characteristics
Characters | Institution 1 (training set) N = 82 | Institution 2 (testing set) N = 73 | P-value |
|---|---|---|---|
pCR | 39 (47.5) | 24 (32.9) | 0.073 |
Age, years (median, IQR) | 62 (56, 66) | 62 (55, 67) | 0.836 |
Sex | Â | Â | 0.304 |
 Female | 16 (19.6) | 11 (15.1) |  |
  Male | 66 (80.4) | 62 (84.9) |  |
KPS |  |  | < 0.001 |
 ≤ 80 | 48 (58.5) | 13 (17.8) |  |
 > 80 | 34 (41.5) | 60 (82.2) |  |
Location | Â | Â | 0.935 |
 Neck | 0 (0.0) | 1 (1.4) |  |
 Upper thoracic | 9 (11.0) | 7 (9.6) |  |
 Middle thoracic | 29 (35.4) | 28 (38.3) |  |
 Lower thoracic | 42 (51.2) | 36 (49.3) |  |
 Gastroesophageal junction | 2 (2.4) | 1 (1.4) |  |
Length, cm (median, IQR) | 5 (4.0, 6.2) | 5 (4.0, 7.0) | 0.461 |
cT | Â | Â | 0.781 |
 1 | 1 (1.2) | 1 (1.4) |  |
 2 | 4 (4.9) | 3 (4.1) |  |
 3 | 53 (64.6) | 53 (72.6) |  |
 4 | 24 (29.3) | 16(21.9) |  |
cN | Â | Â | 0.173 |
 0 | 9 (11.0) | 2 (2.7) |  |
 1 | 22 (26.8) | 27 (37.0) |  |
 2 | 42 (51.2) | 36 (49.3) |  |
 3 | 9 (11.0) | 8 (11.0) |  |
cM | Â | Â | 0.030 |
 0 | 76 (92.7) | 73 (100) |  |
 1 | 6 (7.3) | 0 (0.0) |  |
Chemotherapy regimen | Â | Â | 0.009 |
Platinum based | 62 (75.6) | 66 (90.4) | Â |
Non-platinum based | 20 (24.4) | 7 (9.6) | Â |
Radiotherapy technique |  |  | < 0.001 |
IMRT | 13 (15.9) | 73 (100) | Â |
VMAT | 69 (84.1) | 0 (0.0) | Â |
Radiation dose, Gy (median, IQR) | 41.4 (37.8, 41.4) | 40.0 (40.0, 40.0) | 0.142 |
Simultaneous integrated boost | 63 (76.8) | 0 (0.0) | < 0.001 |
Interval between nCRT and surgery, days (median, IQR) | 57 (48, 79) | 47 (40, 52) | < 0.001 |