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Table 3 Uni- and multivariable Cox regression analyses of factors associated with all-cause mortality using backward elimination in all patients (n = 124, n = 98 events)

From: Management of varices but not anticoagulation is associated with improved outcome in patients with HCC and macrovascular tumour invasion

Patient characteristics

Univariable

Multivariable first step

Multivariable last step

HR (95%CI)

p-value

aHR (95%CI)

p-value

aHR (95%CI)

p-value

Age, per year

1.00 (0.98–1.03)

0.767

1.00 (0.98–1.02)

1.000

–

–

Sex, male vs. female

1.03 (0.54–1.97)

0.931

0.99 (0.51–1.91)

0.969

–

–

Cirrhosis

1.52 (0.84–2.73)

0.164

1.13 (0.58–2.23)

0.714

–

–

EHS

1.69 (1.17–2.43)

0.005

1.21 (0.82–1.79)

0.328

–

–

ECOG PS, 1 vs. 0

1.79 (1.26–2.55)

0.001

1.66 (1.15–2.40)

0.007

1.73 (1.24–2.42)

0.001

CTP score, per point

1.41 (1.09–1.84)

0.010

–

–

–

–

ALBI score, per point

2.15 (1.40–3.30)

< 0.001

1.82 (1.11–2.98)

0.017

2.04 (1.30–3.21)

0.035

Degree of thrombus-induced vessel occlusion

 Partial

1

–

1

–

1

–

 Total

1.60 (1.11–2.31)

0.012

1.47 (1.04–2.07)

0.027

1.44 (1.03–2.02)

0.035

Thrombus localization

 MPV not involved

1

–

1

–

–

–

 MPV involved

0.96 (0.66–1.40)

0.824

1.26 (0.87–1.82)

0.214

–

–

Effective systemic therapy

0.26 (0.16–0.41)

< 0.001

0.26 (0.16–0.41)

< 0.001

0.26 (0.16–0.40)

< 0.001

Non-selective beta blocker therapy

0.81 (0.57–1.14)

0.227

0.71 (0.50–1.00)

0.052

0.75 (0.54–1.05)

0.098

Therapeutic anticoagulation

0.71 (0.42–1.19)

0.190

0.88 (0.55–1.41)

0.596

–

–

  1. Abbreviations: ALBI albumin-to-bilirubin score, (a)HR (adjusted) hazard ratio, CTP Child-Turcotte-Pugh score, ECOG PS Eastern Cooperative Oncology Group Performance Status, EHS extrahepatic spread, MPV main portal vein